中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (20): 1783-1786.doi: 10.4103/1673-5374.143422

• 综述:脊髓损伤修复保护与再生 •    下一篇

新模型研究血管损伤影响脊髓损伤后的结局恢复

  

  • 收稿日期:2014-10-09 出版日期:2014-10-25 发布日期:2014-10-25

Impact of vasculature damage on the outcome of spinal cord injury: a novel collagenase-induced model may give new insights into the mechanisms involved

Patrick Losey, Daniel C. Anthony   

  1. Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford, UK
  • Received:2014-10-09 Online:2014-10-25 Published:2014-10-25
  • Contact: Patrick Losey, DPhil, Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford, UK, patrick.losey@merton.oxon.org.

摘要:

中枢神经系统不具有像周围神经系统一样的可塑性,并且外伤性脊髓损伤会给脊髓造成不可逆损伤。除了最初的机械性损伤,还将伴随长期持久的级联性损伤,即继发性损伤,继发性损伤发生后会引起进一步的轴突损伤和神经元死亡。继发性损伤机制包括出血、组织缺血、血脊髓屏障破裂、炎症、谷氨酸盐毒性,以及脱髓鞘,细胞凋亡性信号传导等。大约在100年前,Allen认为存在于出血中的有害物质可能导致进一步的脊髓损伤。

Abstract:

The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome. Vascular damage leads to decreased blood flow to the cord and the release of potentially toxic blood-borne components. Here we consider the mechanisms that may be contributing to hemorrhage-induced damage and discuss the utility of a new model of spinal cord hemorrhage, which was urgently required as most of our current understanding has been extrapolated from intracerebral hemorrhage studies.

Key words: spinal cord injury, vasculature, hemorrhage, animal model, collagenase, stereotaxic microinjection