中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1739-1740.doi: 10.4103/1673-5374.170296

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓背根神经撕脱损伤后的感觉再生

  

  • 收稿日期:2015-10-15 出版日期:2015-12-07 发布日期:2015-12-07

Sensory regeneration in dorsal root avulsion

Jan Hoeber*   

  1. Uppsala University, Department of Neuroscience, Uppsala, Sweden
  • Received:2015-10-15 Online:2015-12-07 Published:2015-12-07
  • Contact: Jan Hoeber, jan.hoeber@neuro.uu.se.
  • Supported by:

    Our research was supported by the Swedish Research Council (Project Nos. 5420 and 20716), Stiftelsen Olle Engkvist Byggmastare and Signhild
    Engkvist’s Stiftelse. I also thank all co-authors that were involved in this project, namely Carl Trolle, Niclas Konig, Zhongwei Du, Alessandro
    Gallo, Emmanuel Hermans, Håkan Aldskogius, Peter Shortland, Su-Chun Zhang, Ronald Deumens & Elena N. Kozlova. Special thanks to Carl Trolle, Niclas Konig, Håkan Aldskogius and Elena Kozlova for valuable comments on the paper.

摘要:

研究结果显示,被移植入的干细胞可以作为一座“桥梁”来促进损伤的感觉神经纤维在脊髓中生长,重建功能性的神经连接,从而恢复缺失的感觉功能。这种移植的干细胞会分化形成对神经系统特殊的不同成熟水平的多种类型的细胞,目前研究者并没有发现干细胞移植后有任何肿瘤发生或功能性异常的迹象,这就为后期研究人员进行胚胎干细胞的移植提供了新的线索。

Abstract:

Brachial as well as lumbosacral plexus avulsion injuries are usually caused by high kinetic traumas, such as car-pedestrian, car and motorcycle accidents or falls from great heights. Traction forces affecting the head and shoulders or extremities pull the spinal nerve sleeves away from the spinal cord thus tearing and rupturing the postganglionic spinal root until it is avulsed from the spinal cord. In so called central avulsion injuries, the spinal root is avulsed at the interface between the central and peripheral nervous system (CNS and PNS).  This results not only in the disconnection of the root from the cord but also in a longitudinal spinal cord injury. The complexity of the injury leads to degeneration of the spinal root and a marked inflammatory response of the spinal cord followed by the formation of a glial scar. The study provides the first evidence that sensory regeneration across the CNS-PNS interface through growth permissive gates formed by engrafted hNP spheres can be achieved also in dorsal root avulsion. The mechanism behind the formation of growth permissive gates remains elusive and topographically specific regeneration will most likely require combinatorial approaches that are able to guide sensory axons after entering the spinal cord.