中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1743-1745.doi: 10.4103/1673-5374.170298

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

修饰雪旺细胞表型促进周围神经再生的新方法

  

  • 收稿日期:2015-10-12 出版日期:2015-12-07 发布日期:2015-12-07
  • 基金资助:

    德国研究委员会资助

Novel approaches for the development of peripheral nerve regenerative therapies

Felix Beyer, Patrick Küry *   

  1. Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
  • Received:2015-10-12 Online:2015-12-07 Published:2015-12-07
  • Supported by:

    Our research on Schwann cell differentiation was supported by grants from the DFG (German Research Council), Novartis Pharma GmbH (Nürnberg, Germany), and Baxter Innovations GmbH (Vienna, Germany)

摘要:

神经再生过程可分为3个阶段:轴突芽生;再生轴突的生长、延伸;恢复神经支配原靶器官。其中,雪旺细胞因其在周围神经结构组成中的特殊地位和作用,一直是研究的重点。在本文中,作者对实验室的2项临床前调查进行了分析,描述了现有药物治疗可能对雪旺细胞分化的影响及其潜在的表型修饰方法,认为这可以为治疗周围神经损伤患者新药物研发提供新的方法。

Abstract:

The search for active ingredients in polyvalent immunoglobulin preparations (Fc receptor or Schwann cell antigen–directed) as well as studies of S1P receptor activation by means of more specific ligands might further pave the way for novel repair therapies for patients with different peripheral nerve conditions. The studies presented here also demonstrate that Schwann cells exert a high degree of immunocompetence and that multiple signaling interfaces between immune and Schwann cells exist, and these could be explored for pharmacological modulation.