中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (9): 1379-1384.doi: 10.4103/1673-5374.191197

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

药物和细胞治疗减轻创伤性脑损伤后炎症

  

  • 收稿日期:2016-08-26 出版日期:2016-09-30 发布日期:2016-09-30
  • 基金资助:
    4个NIH基金

Utilizing pharmacotherapy and mesenchymal stem cell therapy to reduce in?ammation following traumatic brain injury

Sherwin Mashkouri, Marci G. Crowley, Michael G. Liska, Sydney Corey, Cesar V. Borlongan*   

  1. Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
  • Received:2016-08-26 Online:2016-09-30 Published:2016-09-30
  • Contact: Cesar V. Borlongan, Ph.D., cborlong@health.usf.edu.
  • Supported by:
    This work was funded by NIH R01NS071956, NIH R01 NS090962, NIH R21NS089851, NIH R21 NS094087, DOD W81XWH-11-1-0634, and VA Merit Review I01 BX001407 to CVB.

摘要:

慢性创伤性脑损伤的病理过程与炎症扩散、细胞死亡及神经功能障碍相关。研究认为,隔离炎症介质可以促进细胞及其再生环境的恢复。为了减少与损害血脑屏障的完整性相关的脑水肿和神经变性炎症,美国南佛罗里达州Morsani医学院神经外科和脑修复学系Cesar V. Borlongan教授通过使用药物和细胞疗法控制创伤性脑损伤后炎症。单纯抗炎药物或者细胞治疗的研究已经取得了积极的成果,他们正试图采用联合治疗的方法来治疗炎症。联合使用抗炎药物与干细胞移植可能为脑外伤患者提供更好的临床疗效。尽管前期的动物实验显示出较好的疗效,由动物实验到临床应用的转化还需要更多的动物实验室和较大样本的临床前试验的验证。

orcid: 0000-0002-2966-9782 (Cesar V. Borlongan)

Abstract: The pathologic process of chronic phase traumatic brain injury is associated with spreading in?ammation, cell death, and neural dysfunction. It is thought that sequestration of in?ammatory mediators can facilitate recovery and promote an environment that fosters cellular regeneration. Studies have targeted post-traumatic brain injury in?ammation with the use of pharmacotherapy and cell therapy. These therapeutic options are aimed at reducing the edematous and neurodegenerative in?ammation that have been associated with compromising the integrity of the blood-brain barrier. Although studies have yielded positive results from anti-in?ammatory pharmacotherapy and cell therapy individually, emerging research has begun to target in?ammation using combination therapy. The joint use of anti-in?ammatory drugs alongside stem cell transplantation may provide better clinical outcomes for traumatic brain injury patients. Despite the promising results in this feld of research, it is important to note that most of the studies mentioned in this review have completed their studies using animal models. Translation of this research into a clinical setting will require additional laboratory experiments and larger preclinical trials.

Key words: stem cells, drugs, neuroinflammation, trauma, neuroprotection, regeneration