中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (9): 1464-1470.doi: 10.4103/1673-5374.191221

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

猕猴神经干细胞移植可促进海马损伤大鼠的神经再生

  

  • 收稿日期:2016-08-02 出版日期:2016-09-30 发布日期:2016-09-30
  • 基金资助:
    中国国家自然科学基金项目(31571109, 81460261);中国-芬兰联合项目基金(813111172);云南省重点科研项目(2014FC005);海南省重点科研项目(ZDYF2016156);国家临床重点学科基金项目

Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions

Li-juan Ye1, 2, 4, Hui Bian3, Yao-dong Fan1, Zheng-bo Wang2, Hua-lin Yu4, *, Yuan-ye Ma2, *, Feng Chen5, *   

  1. 1 Department of Pathology, Third Affliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China 2 Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China 3 Department of Physiology, Kunming Medical University, Kunming, Yunnan Province, China 4 Second Department of Neurosurgery, First Affliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China 5 Department of Radiology, Hainan General Hospital, Haikou, Hainan Province, China
  • Received:2016-08-02 Online:2016-09-30 Published:2016-09-30
  • Contact: Feng Chen, Ph.D., Yuan-ye Ma, Ph.D., or Hua-lin Yu, Ph.D., fenger0802@163.com, yuanma0716@sina.com, or yhl308@126.net
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China.

摘要:

猕猴神经干细胞能分化为神经元和神经胶质细胞,因而神经干细胞移植可促进神经功能的恢复。实验将1×105/μL猕猴神经干细胞注射至海马损伤大鼠双侧海马中,经激光共聚焦显微镜观察证实,绿色荧光蛋白标记的移植细胞能够存活下来并良好生长;移植细胞不仅存在于病变区域,还存在于大脑皮质和胼胝体的神经纤维富集区,部分移植细胞有神经元轴突养长突起,整合到大脑表面。经行为学检测大鼠空间学习能力和记忆能力明显改善,说明猕猴神经干细胞能明显改善海马损伤大鼠的空间学习和记忆能力。 

orcid: 0000-0002-9129-7895 (Feng Chen) 0000-0001-5291-9367 (Yuan-ye Ma) 0000-0002-1105-3867 (Hua-lin Yu)

关键词: 神经再生, 猕猴, 神经干细胞, 海马损伤, 细胞移植, 空间学习记忆能力