中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (1): 172-178.doi: 10.4103/1673-5374.243722

• 原著:神经损伤修复保护与再生 • 上一篇    

疼痛面部表情引起疼痛共情的脑机制：一项基于fMRI激活似然估计法的Meta分析

  

  • 出版日期:2019-01-15 发布日期:2019-01-15
  • 基金资助:

    国家自然科学基金资助（81473769，81772430；基金负责人：吴文）；2016年广东省南方医科大学本科生创新与创业培训项目(201612121057；基金负责人：吴文)

Brain pathways of pain empathy activated by pained facial expressions: a meta-analysis of fMRI using the activation likelihood estimation method

Ruo-Chu Xiong1, Xin Fu1, Li-Zhen Wu1, Cheng-Han Zhang1, Hong-Xiang Wu1, Yu Shi2, Wen Wu2   

  1. 1 Clinical Medicine, First Clinical Medicine School, Southern Medical University, Guangzhou, Guangdong Province, China
    2 Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Wen Wu, MD, wuwen66@163.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81473769 (to WW), 81772430 (to WW); a grant from the Training  Program of Innovation and Entrepreneurship for Undergraduates of Southern Medical University of Guangdong Province of China in 2016, No. 201612121057 (to WW) .

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摘要：

目的：利用激活似然估计(Activation Likelihood Estimation，ALE)的Meta分析方法对观看疼痛表情引起疼痛共情的脑机制进行归纳和分析。
资料来源：计算机检索SCI，Science Direct，Pubmed，Deepdyve，Cochrane中心，中国生物医学文献数据库，万方数据库，维普数据库以及中国知网等，检索时限均从建库起至2016年12月13日。
资料选择：所选文献为基于fMRI的研究；试验提供中性及疼痛的面部表情刺激；试验对象中含有“正常被试者”(即共情能力与正常人无差异，基础状态为无痛)；试验对象年龄超过18岁；研究结果呈现形式必须是Talairach或MNI坐标；来自同一团队研究的文献必须采用不同的原始数据。
结局评价指标：受试者在疼痛表情刺激下，利用ALE计算合并后的主要激活脑区。
结果：最终纳入8项试验，共178名受试者。Meta分析结果表明：在疼痛表情刺激下，利用ALE计算合并后激活的主要脑区有前扣带回(BA32)、中央前回(BA44)、梭状回、脑岛(BA13)。
结论：文章分析得出了观看疼痛表情刺激引起疼痛共情激活的脑区，为进一步探究疼痛共情相关的脑机制提供了临床支撑数据。

orcid: 0000-0002-5576-2999(Wen Wu)

关键词: 面部表情, 疼痛共情, fMRI, GringleALE, 激活似然评估法, 脑功能成像, 前扣带回, 中央前回, 梭状回, 脑岛

Abstract:

OBJECTIVE: The objective of this study is to summarize and analyze the brain signal patterns of empa¬thy for pain caused by facial expressions of pain utilizing activation likelihood estimation, a meta-analysis method.
DATA SOURCES: Studies concerning the brain mechanism were searched from the Science Citation Index, Science Direct, PubMed, DeepDyve, Cochrane Library, SinoMed, Wanfang, VIP, China National Knowledge Infrastructure, and other databases, such as SpringerLink, AMA, Science Online, Wiley Online, were collected. A time limitation of up to 13 December 2016 was applied to this study.
DATA SELECTION: Studies presenting with all of the following criteria were considered for study in¬clusion: Use of functional magnetic resonance imaging, neutral and pained facial expression stimuli, involvement of adult healthy human participants over 18 years of age, whose empathy ability showed no difference from the healthy adult, a painless basic state, results presented in Talairach or Montreal Neuro¬logical Institute coordinates, multiple studies by the same team as long as they used different raw data.
OUTCOME MEASURES: Activation likelihood estimation was used to calculate the combined main acti¬vated brain regions under the stimulation of pained facial expression.
RESULTS: Eight studies were included, containing 178 subjects. Meta-analysis results suggested that the anterior cingulate cortex (BA32), anterior central gyrus (BA44), fusiform gyrus, and insula (BA13) were activated positively as major brain areas under the stimulation of pained facial expression.
CONCLUSION: Our study shows that pained facial expression alone, without viewing of painful stimuli, activated brain regions related to pain empathy, further contributing to revealing the brain’s mechanisms of pain empathy.

Key words: nerve regeneration, facial expression, pain empathy, functional magnetic resonance imaging, GringleALE, activation likelihood estimation, brain function imaging, anterior cingulate cortex, anterior central gyrus, fusiform gyrus, insula, neural regeneration