中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (5): 875-879.doi: 10.4103/1673-5374.268907

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

观看不同强度抓握力期间大脑的激活情况:功能磁共振成像研究

  

  • 出版日期:2020-05-15 发布日期:2020-06-01
  • 基金资助:

    韩国教育部国家研究基金会(NRF)基础科学研究计划(2017R1D1A1B03033985)和韩国政府国家研究基金会(NRF)资助

Brain activation induced by different strengths of hand grasp: a functional magnetic resonance imaging study

Hyeok Gyu Kwon1, Ju Sang Kim2, Mi Young Lee3   

  1. 1 Department of Physical Therapy, College of Health Science, Eulji University, Gyeonggi, Republic of Korea
    2 Department of Physical Therapy and Rehabilitation, Yeungnam University Hospital, Daegu, Republic of Korea
    3 Department of Physical Therapy, College of Health and Therapy, Daegu Haany University, Gyeongsansi, Republic of Korea
  • Online:2020-05-15 Published:2020-06-01
  • Contact: Mi Young Lee, PhD,mykawai@hanmail.net.
  • Supported by:
    This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1D1A1B03033985; to MYL) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2018R1A5A2025272; to MYL).

摘要:

通过观看并执行动作可以激活镜像神经元系统(MNS)。为了解健康人观看不同强度握力期间大脑的激活情况,分别让20名成年右利手健康受试者观看显示一只手轻抓或紧抓并重复释放一个球的视频。应用fMRI对受试者观看手部抓握视频时大脑激活情况进行检测。感兴趣区域为下顶叶小叶(IPL),下额回和上颞沟。轻抓或紧抓时,下顶叶小叶、梭形、后中央回、枕叶、颞叶和额回被激活。观看强有力的抓握期间,镜像神经元系统的核心脑区下顶叶小叶的激活水平高于观看轻抓握动作时。这一研究结果可能有助于脑损伤患者康复措施的实施。该研究于201798日获得韩国大邱海明大学大邱东方医院机构审查委员会批准(批准号DHUMC-D-17020-PRO-01)。

orcid: 0000-0002-8858-9360 (Mi Young Lee)

关键词: fMRI, 镜神经系统, 下顶叶小叶, 轻抓, 紧抓, 动作观察, 脑激活, 人脑

Abstract: Mirror neuron system can be activated by observation and execution of an action. It has an important function of action understanding. We investigated brain activations in humans by observing the strength of a hand grasp using functional magnetic resonance imaging. Twenty right-handed healthy individuals, consisting of 10 males and 10 females, aged 22.40 ± 2.04 years, were recruited into this study from September to November 2017 via posters. Light hand grasp task video showed a hand lightly grasping and releasing a ball repeatedly. Powerful hand grasp task video showed a hand tightly grasping and releasing a ball repeatedly. Functional magnetic resonance imaging block design paradigm comprised five stimulation blocks alternating with five baseline blocks. Stimulation blocks were presented with two stimulus tasks, consisting of a light grasp and a powerful grasp. Region of interest was defined around the inferior parietal lobule, inferior frontal gyrus, and superior temporal sulcus which have been called mirror neuron system. The inferior parietal lobule, fusiform, postcentral, occipital, temporal, and frontal gyri were activated during light and powerful grasp tasks. The BOLD signal response of a powerful grasp was stronger than that of a light grasp. These results suggest that brain activation of the inferior parietal lobule, which is the core brain region of the mirror neuron system, was stronger in the powerful grasp task than in the light grasp task. We believe that our results might be helpful for instructing rehabilitation of brain injury. This study was approved by the Institutional Review Board of Daegu Oriental Hospital of Daegu Haany University on September 8, 2017 (approval No. DHUMC-D-17020-PRO-01).

Key words: brain activation, fMRI, human brain, inferior parietal lobule, light grasp, mirror neuron system, powerful grasp