中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 133-134.doi: 10.4103/1673-5374.343900

• 观点:退行性病与再生 • 上一篇    下一篇

neuregulin-1beta1 在多发性硬化发病机制和进展中的新作用

  

  • 出版日期:2023-01-15 发布日期:2022-06-17

Emerging role of neuregulin-1beta1 in pathogenesis and progression of multiple sclerosis

Seyyed Mohyeddin Ziaee, Soheila Karimi-Abdolrezaee*    

  1. Department of Physiology and Pathophysiology, Spinal Cord Research Center, Rady Faculty of Health Sciences, University of Manitoba, Children Hospital Research Institute of Manitoba, Winnipeg, MB, Canada 
  • Online:2023-01-15 Published:2022-06-17
  • Contact: Soheila Karimi-Abdolrezaee, PhD, Soheila.Karimi@umanitoba.ca.
  • Supported by:
    SMZ was supported by a University of Manitoba Graduate Fellowship, Graduate Enhancement of Tri-council Supplement (GETS) and Hillary Kaufman Lerner Memorial Funds. SKA was supported by the grants from Multiple Sclerosis Society of Canada (EGDI-2936, EGDI-3742) and the Canadian Institute of Health Research (133721 and 156218). 

摘要: https://orcid.org/0000-0002-0683-2663 (Soheila Karimi-Abdolrezaee)

Abstract: Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system (CNS) that causes focal demyelinating lesions, followed by axonal and neuronal degeneration. Several genetic and environmental factors are found to be associated with MS incidence. While MS etiology seems to be multifactorial and needs further elucidation, it is understood that the response of an immune system to specific myelin antigens triggers the onset of MS (Dendrou et al., 2015). However, how the autoimmune response initiates against myelin, and the cellular and molecular mechanisms underpinning the development and progression of MS are not fully understood. Thus, deconstructing MS pathogenesis is of paramount importance for identifying novel diagnostic and therapeutic targets for this complex disease.