中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (1): 201-202.doi: 10.4103/NRR.NRR-D-23-02102

• 观点:退行性病与再生 • 上一篇    下一篇

生物标志物半身像:荟萃分析表明神经元细胞外小泡诊断帕金森病的不可靠性

  

  • 出版日期:2025-01-15 发布日期:2025-01-15

Biomarker bust: meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

Hash Brown Taha*   

  1. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Hash Brown Taha, MS, hashbrown@ucla.edu.

摘要: https://orcid.org/0009-0007-3056-8878 (Hash Brown Taha)

Abstract: A range of neurodegenerative disorders, collectively termed parkinsonian disorders, present with a complex array of both motor and non-motor symptoms. Included in this group are Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), corticobasal syndrome (CBS), and progressive supranuclear palsy (PSP). These disorders are differentiated neuropathologically by their dominant protein pathologies involving α-synuclein (α-syn) and/or tau, the types of brain cells affected, such as neurons, oligodendroglia, and astrocytes, and the specific brain regions involved (Tolosa et al., 2021). However, because definite diagnosis can only be achieved postmortem, parkinsonian disorders commonly pose diagnostic challenges for experts in movement disorders due to parkinsonism symptom overlap (Figure 1) including bradykinesia, rigidity, and tremor. This is especially problematic in the early stages of the conditions where more distinguishable symptoms may not be yet present (Rizzo et al., 2016).