中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (3): 836-844.doi: 10.4103/NRR.NRR-D-23-01585

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

促进胸段脊髓损伤患者运动功能恢复: 自主轮跑与强制跑台训练的比较

  

  • 出版日期:2025-03-15 发布日期:2024-06-26

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

Do-Hun Lee1, 2, 3, Dan Cao1, Younghye Moon3, Chen Chen1, 2, Nai-Kui Liu1, 2, Xiao-Ming Xu1, 2, †, Wei Wu1, 2, *   

  1. 1Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; 2Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; 3Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA †Deceased author
  • Online:2025-03-15 Published:2024-06-26
  • Contact: Wei Wu, MD, PhD, wu99@iu.edu.
  • Supported by:
    The work in the Wu laboratory was supported by the NIH (R01NS103481, R01NS111776, and R01NS131489) and Indiana Department of Health (ISDH58180) (all to WW).

摘要:

运动疗法在脊髓损伤功能恢复方面显示出优势。为了解康复运动对挫伤性胸段脊髓损伤后功能恢复和形态变化的影响。经过7天的脊髓损伤恢复期后,小鼠被随机分为训练组(10周的自主轮跑与强制跑台运动训练)或未训练组。每2周一次的评估结果显示,与未经训练的组相比,经过运动训练的组,尤其是自主轮跑运动亚组,运动恢复能力明显提高,而且还能诱导多巴胺能和血清素调节的可塑性。此外,运动干预还能恢复步态,增强脊髓电生理功能。尽管各组的脊髓损伤面积一致,但运动训练促进了轴突的末端神经支配。总之,运动训练有助于胸段挫伤性脊髓损伤后功能的恢复,尤其以自主轮跑运动作用更佳。该研究结果将影响未来的脊髓损伤康复训练策略的制定。

https://orcid.org/0000-0002-7835-4963 (Wei Wu)

Abstract: Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group (10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

Key words: behavioral assessment, motor function, neural plasticity, running wheel exercise, spinal cord injury, treadmill exercise, voluntary exercise