中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (4): 1564-1565.doi: 10.4103/NRR.NRR-D-24-01380

• 观点:退行性病与再生 • 上一篇    下一篇

褪黑素和线粒体应激:与年龄相关神经退行性病的新观点

  

  • 出版日期:2026-04-15 发布日期:2025-07-27

Melatonin and mitochondrial stress: New insights into age-related neurodegeneration

Silvia Carloni# , Francesca Luchetti# , Maria Gemma Nasoni, Walter Balduini* , Walter Manucha* , Russel J. Reiter*   

  1. Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy (Carloni S, Luchetti F, Nasoni MG, Balduini W) Instituto de Medicina y Biologia Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Mendoza, Argentina (Manucha W) Department of Cell Systems and Anatomy, UT Health San Antonio, Long School of Medicine, San Antonio, TX, USA (Reiter RJ)
  • Online:2026-04-15 Published:2025-07-27
  • Contact: Walter Balduini, PhD, walter.balduini@uniurb.it; Walter Manucha, PhD, wmanucha@fcm.uncu.edu.ar; Russel J. Reiter, PhD, reiter@uthscsa.edu.

摘要: https://orcid.org/0000-0001-8438-9559 (Walter Balduini) https://orcid.org/0000-0002-2279-7626 (Walter Manucha) https://orcid.org/0000-0001-6763-4225 (Russel J. Reiter)

Abstract: Aging, mitochondria, and neurodegenerative diseases: Aging is often viewed as the buildup of changes that lead to the gradual transformations associated with getting older, along with a rising likelihood of disease and mortality. Although organism-wide deterioration is observed during aging, organs with high metabolic demand, such as the brain, are more vulnerable. Consequently, most neurodegenerative diseases occur in the aged population. Even in the healthy brain, the normal aging process is associated with several features of the neurodegenerative process, including neuroinflammation, and brain shrinkage, with a progressive decline in physiological functions (Lee and Kim, 2022).