中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 2944-2945.doi: 10.4103/NRR.NRR-D-25-00567

• 观点:退行性病与再生 • 上一篇    下一篇

重新评估肌萎缩侧索硬化症发病中骨骼肌的作用:从肌肉衍生因素获得的见解

  

  • 出版日期:2026-07-15 发布日期:2026-03-27

Reevaluating the role of skeletal muscle in amyotrophic lateral sclerosis pathogenesis: Insights from muscle-derived factors

Pablo Martinez, Brigitte van Zundert, Fernando J. Bustos*   

  1. Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Institute of Biomedical Sciences (ICB), Faculty of Medicine & Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile 
    Millennium Nucleus of Neuroepigenetics and Plasticity (EpiNeuro), Santiago, Chile
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Fernando J. Bustos, PhD, Fernando.bustos@unab.cl.
  • Supported by:
    This work was supported by ANID Fondecyt Regular 1250955 (to FJB), ANID Fondecyt Regular 1221745 (to BvZ), UNAB DI-06-24/REG (to FJB), and ANID MILENIO (NCN2023_32, to BvZ and FJB).

摘要: https://orcid.org/0000-0002-0487-7032 (Fernando J. Bustos)

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease marked by motor neuron (MN) degeneration, neuromuscular junction disruption, and muscle atrophy, ultimately leading to paralysis and death. Despite extensive research, no effective treatment exists, highlighting the need to elucidate mechanisms driving ALS pathogenesis.