中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4267-4268.doi: 10.4103/NRR.NRR-D-25-01793

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

基因递送到小鼠大脑:促进疾病建模和基因治疗

  

  • 出版日期:2026-09-15 发布日期:2026-05-14

Gene delivery to the mouse brain: Facilitating disease modeling and gene therapy

Osama Ahmed, Aliaa Elshamy, Abraam Yakoub*   

  1. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA (Ahmed O, Yakoub A)
    Department of Biomedical Engineering, University of North Dakota, Grand Forks, ND, USA (Ahmed O)
    Department of Microbiology and Immunology, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt (Elshamy A)
  • Online:2026-09-15 Published:2026-05-14

摘要: https://orcid.org/0000-0001-7096-9923 (Abraam Yakoub)

Abstract: Gene delivery to the mouse brain is essential for neural circuit probing or therapeutic testing. We describe viral approaches for gene delivery to the mouse brain, and outline the applications and limitations of each approach, and strategies to mitigate the limitations. We provide a decisionoriented guide to the optimal vector and route combinations for the mouse brain, to facilitate studying brain functions or testing gene therapies in vivo.