Artifcial guidance channels containing Schwann cells can promote the regeneration of injured peripheral nerve over long distances. However, primary Schwann cells are not suitable for autotransplantation. Under specifc conditions, skin-derived progenitors can be induced to differentiate into Schwann cells. Therefore, Dr. Jianghai Chen and co-workers from Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China collected adult rat dorsal skin (dermis)-derived progenitors that were isolated and induced to differentiate with DMEM/F12 containing B27, neuregulin 1, and forskolin. Immunofuorescence staining and reverse transcription polymerase chain reaction confrmed that the resultant cells were indeed Schwann cells. By comparing the effects of artifcial guidance channels containing skin-derived progenitors, Schwann cells originating from skin-derived progenitors, or primary Schwann cells used to bridge 5 mm sciatic nerve defects, these researchers found that Schwann cells originating from skin-derived progenitors signifcantly promoted sciatic nerve axonal regeneration. The significant recovery of injured rat sciatic nerve function after the transplantation of Schwann cells originating from skin-derived progenitors was confrmed by electromyogram. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 18, 2014).
Article: "Schwann cells originating from skin-derived precursors promote peripheral nerve regeneration in rats," by Ping Zhang1, Xiaocheng Lu2, Jianghai Chen2, Zhenbing Chen2 (1 Department of Orthopedics, Wuhan Women and Children Health Care Center, Wuhan, Hubei Province, China; 2 Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China)
Zhang P, Lu XC, Chen JH, Chen ZB. Schwann cells originating from skin-derived precursors promote peripheral nerve regeneration in rats. Neural Regen Res. 2014;9(18):1696-1702.
Contact: Meng Zhao
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含有许旺细胞的人工导管能显著促进长距离周围神经缺损的修复，但原代许旺细胞不适宜自体移植，而皮肤源性前体细胞可在特定的条件下被诱导分化为许旺细胞，为提供许旺细胞的来源。来自中国华中科技大学同济医学院附属协和医院的陈江海博士所在团队，拟收集成年大鼠背侧真皮中皮肤源性前体细胞，以含B27、神经调节蛋白1和forskolin的DMEM/F12诱导分化，并证实所获细胞为许旺细胞。通过对比复合皮肤源性前体细胞、许旺细胞或皮肤源性前体细胞源性许旺细胞的硅胶管桥接5mm坐骨神经缺损的效果，发现皮肤源性前体细胞源性许旺细胞可明显促进移植后损伤坐骨神经轴突的再生，肌电图证实皮肤源性前体细胞源性许旺细胞移植后大鼠损伤坐骨神经功能明显恢复。相关文献发表于《中国神经再生研究（英文版）》杂志2014年9月第18期。
Article: "Schwann cells originating from skin-derived precursors promote peripheral nerve regeneration in rats," by Ping Zhang1, Xiaocheng Lu2, Jianghai Chen2, Zhenbing Chen2 (1 Department of Orthopedics, Wuhan Women and Children Health Care Center, Wuhan, Hubei Province, China; 2 Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China)
Zhang P, Lu XC, Chen JH, Chen ZB. Schwann cells originating from skin-derived precursors promote peripheral nerve regeneration in rats. Neural Regen Res. 2014;9(18):1696-1702.
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