中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (29): 2299-2304.

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

离断坐骨神经以外膜缝合和束膜缝合法缝合后吻合口应力应变分析

  

  • 收稿日期:2012-04-06 修回日期:2012-07-24 出版日期:2012-10-15 发布日期:2012-10-15

Stress and strain analysis on the anastomosis site sutured with either epineurial or perineurial sutures after simulation of sciatic nerve injury

Guangyao Liu1, Qiao Zhang1, Yan Jin2, Zhongli Gao1   

  1. 1 Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin Province, China
    2 Department of Ophthalmology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China
  • Received:2012-04-06 Revised:2012-07-24 Online:2012-10-15 Published:2012-10-15
  • Contact: Yan Jin, M.D., Associate profes-sor, Department of Ophthal-mology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China jy@jiu.edu.cn
  • About author:Guangyao Liu☆, M.D., Professor, Department of Orthopedics, China-Japan Union Hospital, Jilin Univer-sity, Changchun 130031, Jilin Province, China

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Abstract:

The magnitude of tensile stress and tensile strain at an anastomosis site under physiological stress is an important factor for the success of anastomosis following suturing in peripheral nerve injury treatment. Sciatic nerves from fresh adult cadavers were used to create models of sciatic nerve injury. The denervated specimens underwent epineurial and perineurial suturing. The elastic modulus (40.96 ± 2.59 MPa) and Poisson ratio (0.37 ± 0.02) of the normal sciatic nerve were measured by strain electrical measurement. A resistance strain gauge was pasted on the front, back, left, and right of the edge of the anastomosis site after suturing. Strain electrical measurement results showed that the stress and strain values of the sciatic nerve following perineurial suturing were lower than those following epineurial suturing. Scanning electron microscopy revealed that the sciatic nerve fibers were disordered following epineurial compared with perineurial suturing. These results indicate that the effect of perineurial suturing in sciatic nerve injury repair is better than that of epineurial suturing.

Key words: sciatic nerve injury, epineurial suture, perineurial suture, strain electrical measurement, anastomosis site, tensile stress, tensile strain, elastic modulus, Poisson ratio, biomechanics, peripheral nerve injury, neural regeneration