中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (9): 1372-1374.doi: 10.4103/1673-5374.191195

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

纳米材料与神经再生

  

  • 收稿日期:2016-06-13 出版日期:2016-09-30 发布日期:2016-09-30

Nanobiomaterials for neural regeneration

Nuan Chen1, Lingling Tian1, Liumin He2, Seeram Ramakrishna1, 3, *   

  1. 1 Center for Nanofbers and Nanotechnology, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore 2 Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong Province, China 3 Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, Guangdong Province, China
  • Received:2016-06-13 Online:2016-09-30 Published:2016-09-30
  • Contact: Seeram Ramakrishna, Ph.D., seeram@nus.edu.sg; seeram.rk@gmail.com.

摘要:

与神经系统相关的疾病和病症,例如创伤和神经退变损伤被证明是医学中最严重的问题之一,需要创新策略来触发和增强神经再生。组织工程旨在通过使用细胞,材料和合适的生物线索组合来提供高仿生环境,通过该组合,丢失的身体部分可以被再生甚至完全重建。静电纺丝,能够产生具有设计和材料选择具有极大灵活性的细胞外基质样纳米结构,这表明了它们制造神经组织工程支架的巨大潜力。这篇综述文章首先简要描述了神经系统解剖内容,为神经组织支架的设计提供基本的知识和想法,其次是电纺神经组织工程支架设计中的五个主要部分,包括材料选择、结构设计、体外生物反应器、功能化和细胞支持。还讨论了仿生电纺纳米纤维神经植入装置的性能。最后,文章讨论了高级电纺神经组织工程支架的未来发展方向。

orcid: 0000-0001-8479-8686 (Seeram Ramakrishna)

Abstract: Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the lost body part may be regenerated or even fully rebuilt. Electrospinning, being able to produce extracellular matrix (ECM)-like nanostructures with great ?exibility in design and choice of materials, have demonstrated their great potential for fabrication of nerve tissue engineered scaffolds. The review here begins with a brief description of the anatomy of native nervous system, which provides basic knowledge and ideas for the design of nerve tissue scaffolds, followed by fve main parts in the design of electrospun nerve tissue engineered scaffolds including materials selection, structural design, in vitro bioreactor, functionalization and cellular support. Performances of biomimetic electrospun nanofibrous nerve implant devices are also reviewed. Finally, future directions for advanced electrospun nerve tissue engineered scaffolds are discussed.

Key words: nerve regeneration, tissue engineering, contact guidance, electrospun scaffold, nanostructured materials, nanofibers