中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (4): 610-613.doi: 10.4103/1673-5374.205100

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

低频重复经颅磁刺激可改善脑梗死后的运动功能障碍

  

  • 收稿日期:2017-03-07 出版日期:2017-04-15 发布日期:2017-04-15
  • 基金资助:

    国家自然科学基金(30540058,30770714);北京市自然科学基金(7052030);北京市委组织部人才基础项目;北京市科技计划项目基金(z0005187040191-1);首都医学发展科研基金(2007-2068

Low frequency repetitive transcranial magnetic stimulation improves motor dysfunction after cerebral infarction

Zhi-yong Meng, Wei-qun Song   

  1. Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, Chin
  • Received:2017-03-07 Online:2017-04-15 Published:2017-04-15
  • Contact: Wei-qun Song, songwq666@163.com.
  • Supported by:

    This project was supported by the National Natural Science Foundation of China, No. 30540058, 30770714; the Natural Science Foundation
    of Beijing of China, No. 7052030; the Talents Foundation of Organization Department of the Beijing Municipal Committee in China; the Beijing Science Plan Project Fund of China, No. Z0005187040191-1; the Research Foundation of Capital Medical Development of China, No. 2007-2068.

摘要:

低频(≤1 Hz)重复经颅磁刺激会影响大脑皮质的兴奋性及突触可塑性,从而促进神经功能恢复,是临床治疗脑梗死较为常用的一种手段,但以往研究对其促进运动功能恢复的具体效果尚无定论。研究纳入脑梗死偏瘫患者20例,随机分2组,低频重复经颅磁刺激组患者10例给予重复经颅磁刺激(对侧初级运动皮质区,1 Hz,刺激强度90%MT,连续刺激30 min/次,1次/d)治疗,对照组10例给予假刺激治疗。治疗14 d后,重复经颅磁刺激组神经功能缺损评分、独立生活活动能力和肢体运动功能评分均较治疗前明显改善,效果优于假刺激组。结果可证实低频(1 Hz)重复经颅磁刺激14 d可有效促进脑梗死后患者的运动功能恢复。

ORCID:0000-0002-5053-5084(Wei-qun Song)

关键词: 神经再生, 脑损伤, 重复经颅磁刺激, 运动功能障碍, 脑梗死, 美国国立卫生研究院卒中量表, Barthel指数, Fugl Meyer评分

Abstract:

Low frequency (≤ 1 Hz) repetitive transcranial magnetic stimulation (rTMS) can affect the excitability of the cerebral cortex and synaptic plasticity. Although this is a common method for clinical treatment of cerebral infarction, whether it promotes the recovery of motor function remains controversial. Twenty patients with cerebral infarction combined with hemiparalysis were equally and randomly divided into a low frequency rTMS group and a control group. The patients in the low frequency rTMS group were given 1-Hz rTMS to the contralateral primary motor cortex with a stimulus intensity of 90% motor threshold, 30 minutes/day. The patients in the control group were given sham stimulation. After 14 days of treatment, clinical function scores (National Institute of Health Stroke Scale, Barthel Index, and Fugl-Meyer Assessment) improved significantly in the low frequency rTMS group, and the effects were better than that in the control group. We conclude that low frequency (1 Hz) rTMS for 14 days can help improve motor function after cerebral infarction.

Key words: nerve regeneration, brain injury, repetitive transcranial magnetic stimulation, motor dysfunction, cerebral infarction, National Institute of Health Stroke Scale, Barthel Index, Fugl-Meyer Assessment, neural regeneration