中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1629-1636.doi: 10.4103/1673-5374.363189

• 综述:脊髓损伤修复保护与再生 •    下一篇

自噬协同干细胞治疗脊髓损伤

  

  • 出版日期:2023-08-15 发布日期:2023-02-16
  • 基金资助:
    国家自然科学基金项目(32170825和31971108)

Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury

Yao Shen1, 2, #, Yi-Piao Wang1, 2, #, Xin Cheng1, 2, Xuesong Yang1, 2, *, Guang Wang1, 2, *   

  1. 1Division of Histology and Embryology, International Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University, Guangzhou, Guangdong Province, China; 2Key Laboratory for Regenerative Medicine of the Ministry of Education, Jinan University, Guangzhou, Guangdong Province, China
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Guang Wang, PhD, wangguang7453@126.com or t_wangguang@jnu.edu.cn; Xuesong Yang, PhD, yang_xuesong@126.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 32170825 and 31971108 (both to GW).

摘要:

干细胞是一类具有自我更新和分化潜力的细胞,其在修复脊髓损伤方面具有很大的前景,但是干细胞的更新和分化活动需要严格控制干细胞中的蛋白质周转来实现细胞重塑。自噬作为高度的保守的细胞稳态的“守门人”,可通过精确控制细胞内的蛋白质周转来调节细胞重塑。最近有研究发现,在脊髓损伤动物模型中可见自噬标志物表达的改变。因此,了解自噬是否会影响干细胞命运,促进脊髓损伤修复有重要的临床价值。文章从脊髓损伤的病理生理、自噬与干细胞功能、脊髓损伤中的自噬与干细胞功能三个方面阐述了自噬稳态控制对于脊髓损伤修复的重要性,提出自噬与干细胞对于脊髓损伤的协同治疗作用。

https://orcid.org/0000-0001-7595-2880 (Guang Wang); https://orcid.org/0000-0002-2537-5752 (Xuesong Yang)

关键词: 自噬, 分子伴侣介导的自噬, 炎症, 氧化应激, 干细胞, 脊髓损伤, 神经干细胞, 间充质干细胞, 诱导性多能干细胞, 胚胎干细胞

Abstract: Stem cells are a group of cells with unique self-renewal and differentiation abilities that have great prospects in the repair of spinal cord injury. However, stem cell renewal and differentiation require strict control of protein turnover in the stem cells to achieve cell remodeling. As a highly conserved “gatekeeper” of cell homeostasis, autophagy can regulate cell remodeling by precisely controlling protein turnover in cells. Recently, it has been found that the expression of autophagy markers changes in animal models of spinal cord injury. Therefore, understanding whether autophagy can affect the fate of stem cells and promote the repair of spinal cord injury is of considerable clinical value. This review expounds the importance of autophagy homeostasis control for the repair of spinal cord injury from three aspects—pathophysiology of spinal cord injury, autophagy and stem cell function, and autophagy and stem cell function in spinal cord injury—and proposes the synergistic therapeutic effect of autophagy and stem cells in spinal cord injury.

Key words: autophagy, chaperone-mediated autophagy, embryonic stem cells, induced pluripotent stem cells, inflammation, mesenchymal stem cells, neural stem cells, oxidative stress, spinal cord injury