中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2124-2140.doi: 10.4103/NRR.NRR-D-24-01239

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

经典和非经典SHH信号通路:与中枢神经系统的复杂关联

  

  • 出版日期:2026-06-15 发布日期:2025-09-16

Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights

Nuokun Li1, #, Shiyi Wen2, #, Dandan Li3 , Yaning Shi1 , Zhigang Mei4 , Danhong Liu4 , Hui Yang5 , Yuhong Wang1 , Xiaoyuan Lin5 , Yun Xiang1, *, Hongbo Wen6, *, Pan Meng1, 4, *   

  1. 1 Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan Province, China;  2 Department of Plastic Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China;  3 Department of Science and Technology, Hunan University of Chinese Medicine, Changsha, Hunan Province, China;  4 School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China;  5 The First Hospital, Hunan University of Chinese Medicine, Changsha, Hunan Province, China;  6 Department of Neurosurgery, Yiyang Central Hospital of Hunan Province, Yiyang, Hunan Province, China
  • Online:2026-06-15 Published:2025-09-16
  • Contact: Hongbo Wen, MS, docwhbo@163.com; Yun Xiang, MS, xiangyun003997@hnucm.edu.cn; Pan Meng, MD, 004181@hnucm.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 82474468 (to PM); the Science and Technology Innovation Program of Hunan Province, No. 2024RC3200 (to PM); the Health Commission Talent Project of Hunan Province, No. 20240304118 (to PM); the Scientific Research Project of Hunan Department of Education, No. 23A0281 (to PM); the Open Fund for Chinese Medicine Powder and Innovative Drugs in the Cultivation Base of the ProvincialMinistry Jointly Established State Key Laboratory of Chinese Medicine, No. 23PTKF1013 (to PM); and the Training Plan of Outstanding Innovative Youth of Changsha, No. kq2009018 (to PM).

摘要:

过去几十年间,Sonic Hedgehog(SHH)蛋白已成为许多生物过程中的关键参与者,包括肿瘤发生、胚胎发育以及脑损伤后的保护机制。SHH信号通路在中枢神经系统中至关重要,与多种疾病相关,包括帕金森病、阿尔茨海默病、脊髓损伤、创伤性脑损伤、抑郁症、SHH髓母细胞瘤和脑卒中。此综述文章从经典和非经典通路的角度探讨了SHH,阐明了其与中枢神经系统的复杂关联。随后,总结了通过调节SHH蛋白来治疗神经系统疾病的最新药物疗法进展,这些疗法提供了新的治疗策略。最后,总结了研究SHH信号传导领域的技术和工具,旨在为相关研究提供新的思路和方法。 

https://orcid.org/0009-0004-7418-1753 (Hongbo Wen); https://orcid.org/0000-0002-8919-7334 (Yun Xiang); 

https://orcid.org/0000-0002-4214-9773 (Pan Meng)

关键词: 阿尔茨海默病, 经典通路, 中枢神经系统疾病, 药物治疗, 神经再生, 非经典通路, Sonic Hedgehog, Sonic Hedgehog髓母细胞瘤, 脑卒中

Abstract: Over the past few decades, the Sonic Hedgehog protein has become a pivotal player in many biological processes, including tumourigenesis, embryonic development, and protective mechanisms after cerebral damage. The Sonic Hedgehog signaling pathway is crucial in the central nervous system, with implications in a diverse range of diseases, including Parkinson’s disease, Alzheimer’s disease, spinal cord injury, traumatic brain injury, depression, Sonic Hedgehog medulloblastoma, and stroke. In this comprehensive review, we examined Sonic Hedgehog from the perspective of canonical and non-canonical pathways, elucidating their complex connections to the central nervous system. Subsequently, we summarize the latest advancements in drug therapies that offer novel strategies for treating neurological diseases by modulating the Sonic Hedgehog protein. Finally, we summarize and extend the technologies and tools for studying the Sonic Hedgehog signaling field, with the aim of providing new research ideas and methods.

Key words: Alzheimer’s disease, canonical, central nervous system disease, drug therapy, neural regeneration, non-canonical, Sonic Hedgehog, Sonic Hedgehog medulloblastoma, stroke