中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4028-4044.doi: 10.4103/NRR.NRR-D-24-01516

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

RF酰胺神经肽受体家族的生理作用、药物开发和结构特征

  

  • 出版日期:2026-09-15 发布日期:2026-05-16

cGAS–STING pathway modulation: A new hope for neural regeneration

Jinghan Zhang1, #, Mouyuan Sun2, *, #, Yaxian Luo2, Mikko Petteri Räisänen3, Lianjie Peng2, Luying Qin2, Mengfei Yu2, *, Haifei Shi1, *   

  1. 1Department of Orthopedics, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China;
    2Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, Zhejiang Province, China; 
    3Department of Orthopedics, Traumatology, and Hand Surgery, Kuopio University Hospital, Kuopio, Finland
  • Online:2026-09-15 Published:2026-05-16
  • Contact: Haifei Shi, MD, shihaifei@zju.edu.cn; Mengfei Yu, MD, yumengfei@zju.edu.cn; Mouyuan Sun, MD, sunmouyuan777@zju.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82272465 (to HS), 82122014 (to MY), 82071085 (to MY); National Key Research and Development Program of China, No. 2023YFB3813003 (to MY); the Natural Science Foundation of Zhejiang Province of China, No. LQN25H140004 (to MY); and China Postdoctoral Science Foundation, Nos. 2024T170782 (to MY), 2023M743009 (to MY).

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摘要：

近年来，治疗干预的局限性使神经系统疾病和损伤在学术研究中占据了重要地位。现有神经治疗方法在促进神经再生方面效果不佳。精准医学技术与创新组织工程方法的结合，为实现神经再生带来了巨大希望。cGAS-STING通路作为先天免疫系统的重要组成部分，在多种神经系统疾病和损伤的病理过程中发挥关键作用。在神经炎症性疾病和神经损伤中，cGAS-STING通路的异常激活会放大神经炎症、I型干扰素反应及细胞死亡。抑制cGAS-STING相关基因有望促进疾病恢复后及缺陷修复过程中的神经再生。文章综述了神经系统疾病和损伤中cGAS-STING相关基因调控的基础病理生理机制，特别强调其在神经细胞中的作用。重点介绍了整合cGAS-STING通路调节剂的组织工程技术进展，突出了其在调节神经再生中的潜在治疗效果。然而，cGAS-STING通路在神经再生中的作用仍相对有限。文献计量学分析显示，cGAS-STING通路激活与多种神经病理过程存在显著相关性。研究逐渐聚焦于该通路在神经系统疾病和损伤中的关键作用。目前，涉及cGAS-STING相关基因调节剂的组织工程技术在实现神经再生方面的有效性尚未充分发挥其潜力。未来研究需运用先进组学技术进一步明确cGAS-STING通路在神经再生中的精确功能。将这些研究成果与精准医学方法相结合，将有助于开发具备精准递送和靶向控制释放cGAS-STING相关基因能力的组织工程生物材料，从而实现神经损伤和疾病后的功能恢复。


https://orcid.org/0000-0001-8159-4610 (Haifei Shi); 

https://orcid.org/0000-0002-7700-4697 (Mengfei Yu); 

https://orcid.org/0000-0002-6377-7648 (Mouyuan Sun)

关键词: 生物材料, cGAS-STING, 神经损伤, 神经再生, 神经退行性疾病, 神经炎症, 精准医学, 组织工程

Abstract: In recent decades, the limitations of therapeutic interventions have elevated neurological disorders and injuries to a prominent position in academic research. Existing neurotherapeutic methodologies have demonstrated insufficient efficacy in fostering neural regeneration. The current integration of precision medicine technologies and innovative tissue engineering methods holds significant promise for attaining neural regeneration. The cGAS–STING pathway, a pivotal component of the innate immune system, plays a crucial role in the pathological processes of various neurological diseases and injuries. In neuroinflammatory diseases and neural injuries, aberrant activation of the cGAS–STING pathway amplifies neuroinflammation, type I interferon responses, and cell death. Inhibition of cGAS–STING-related genes holds promise for promoting neural regeneration following disease recovery and defect regeneration. In this review, the foundational pathophysiological mechanisms underlying cGAS–STING-related gene regulation in neurological disorders and injuries are elucidated with a special emphasis on its implications in nerve-related cells. In this review, we highlight the advances in tissue engineering technologies that integrate cGAS–STING pathway modulators, highlighting their potential therapeutic efficacy in modulating neural regeneration. Nevertheless, the role of the cGAS–STING pathway in neural regeneration remains relatively limited. Bibliometric analysis demonstrates a significant correlation of cGAS–STING pathway activation with various neuropathological processes. Studies have progressively focused on the critical role of this pathway in neurological diseases and injuries. As it stands, the effectiveness of tissue engineering technologies involving cGAS–STING-related gene modulators in achieving neural regeneration remains unfulfilled in its potential. Future research must apply advanced omics technologies to further delineate the exact functions of the cGAS–STING pathway in neural regeneration. Integration of these results with precision medicine approaches will be necessary for creating tissue engineering biomaterials with capabilities for precise delivery and targeted controlled release of cGAS–STING-related genes in neural regeneration-related cells, towards functional recovery from neurological injury and diseases.

Key words: biomaterials, cGAS–STING, nerve injury, neural regeneration, neurodegeneration, neuroinflammation, precision medicine, tissue engineering