中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4177-4194.doi: 10.4103/NRR.NRR-D-25-00020

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

整合素家族在神经系统疾病中的潜力和治疗进展

  

  • 出版日期:2026-09-15 发布日期:2026-05-19

The potential and therapeutic advances of the integrin family in neurological disorders

Xingfang Zhang1, 2, #, Liang Gao1, #, Yiwen Wang2, 3, Qian Meng2, 4, Min Bai2, Dong Xu2, Yanhua Wang2, Jianv Wang1, Hongtao Bi1, *, Yi Ding2, *   

  1. 1Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, Qinghai Province, China; 
    2Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, China; 
    3Department of Pharmacology, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, China; 
    4College of Life Sciences, Northwest University, Xi’an, Shaanxi Province, China
  • Online:2026-09-15 Published:2026-05-19
  • Contact: Yi Ding, PhD, dingyi.007@163.com; Hongtao Bi, PhD, bihongtao@hotmail.com.
  • Supported by:
    This work was financially supported by the National Natural Science Foundation of China, No. 82274313; Project of Shaanxi Administration of Traditional Chinese Medicine, No. 2022-SLRH-YQ-010; G-Project of the 940th Hospital, No. 2024-G3-8; and Key Laboratory of Traditional Chinese Medicine and Pharmacology (all to YD).

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摘要：

神经系统疾病包括一组多样化和异质性的疾病，包括脑血管疾病（如脑卒中）、神经退行性疾病（如阿尔茨海默病和帕金森病）和自身免疫性脱髓鞘疾病（如多发性硬化）。随着全球人口老龄化，这些疾病的发病率继续上升，这对医疗保健系统和社会经济构成重大挑战。最近有研究关注了中枢神经系统功能的关键调节因子整合素（一种跨膜糖蛋白受体家族）在神经疾病的作用。整合素可通过与细胞外基质相互作用，调节细胞黏附、信号转导和炎症反应，且在神经元发育、突触可塑性和血脑屏障维持中发挥不可或缺的作用。且整合素信号失调与多种神经系统疾病的病理生理学有关，这表明整合素靶向干预，如整合素拮抗剂或激动剂，具有治疗潜力。临床前和临床研究表明，调节整合素功能会影响疾病进展，这为精准医学方法的发展提供了前景。此次综述将对整合素结构、分类及其在中枢神经系统中的生理病理作用进行全面概述，重点关注其在神经系统疾病中的分子机制。此外文章还评估了与整合素靶向干预相关的治疗潜力和挑战。通过阐明整合素在中枢神经系统中功能的机制基础，本综述旨在深化我们对其翻译潜力的理解，为创新治疗策略的发展奠定基础。


https://orcid.org/0000-0002-2158-3108 (Yi Ding); 

https://orcid.org/0000-0002-5569-8552 (Hongtao Bi); 

https://orcid.org/0000-0001-7558-378X (Xingfang Zhang);
https://orcid.org/0009-0007-2179-1445 (Liang Gao)

关键词: 阿尔茨海默病, 血脑屏障, 中枢神经系统, 细胞外基质, 出血性卒中, 整合素, 缺血性卒中, 多发性硬化, 神经系统疾病, 帕金森病

Abstract: Neurological disorders encompass a diverse and heterogeneous group of medical conditions, including cerebrovascular diseases (e.g., stroke), neurodegenerative diseases (e.g., Alzheimer’s disease and Parkinson’s disease), and autoimmune demyelinating disorders (e.g., multiple sclerosis). With the global aging population, the incidence of these disorders continues to rise, posing significant challenges to healthcare systems and socio-economic structures. Recent studies have highlighted integrins—a family of transmembrane glycoprotein receptors—as critical regulators of central nervous system function, making them a focal point in neurological disease research. By interacting with the extracellular matrix, integrins modulate cell adhesion, signal transduction, and inflammatory responses, playing indispensable roles in neuronal development, synaptic plasticity, and blood–brain barrier maintenance. Dysregulated integrin signaling has been implicated in the pathophysiology of various neurological disorders, suggesting that integrin-targeting interventions, including integrin antagonists or agonists, could represent novel therapeutic strategies. Preclinical and clinical studies have demonstrated that modulating integrin function influences disease progression, offering promising avenues for the development of precision medicine approaches. This review provides a comprehensive analysis of integrin structure, classification, and their physiological and pathological roles in the central nervous system, with a focus on their molecular mechanisms in neurological disorders. Furthermore, we evaluate the therapeutic potential and challenges associated with integrintargeted interventions. By elucidating the mechanistic underpinnings of integrin function in the central nervous system, this review aims to advance our understanding of their translational potential, laying the groundwork for the development of innovative therapeutic strategies.

Key words: Alzheimer’s disease, blood–brain barrier, central nervous system, extracellular matrix, hemorrhagic stroke, integrin, ischemic stroke, multiple sclerosis, neurological disorders, Parkinson’s disease