中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (7): 1129-1137.doi: 10.4103/1673-5374.251188

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

外源性神经干细胞移植治疗脑缺血

  

  • 出版日期:2019-07-15 发布日期:2019-07-15
  • 基金资助:

    中国国家自然科学基金项目(0040205401797),国家研究项目(15164216)

Exogenous neural stem cell transplantation for cerebral ischemia

Ling-Yi Liao 1 , Benson Wui-Man Lau 2 , Dalinda Isabel Sánchez-Vidaña 2 , Qiang Gao 1, 2   

  1. 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    2 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China
  • Online:2019-07-15 Published:2019-07-15
  • Contact: Qiang Gao, MD, PhD, gaoqiang_hxkf@163.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 0040205401797 (to QG); the General Research Fund of China, No. 15164216 (to BWML).

摘要:

脑缺血性损伤是脑卒中的主要表现形式,其在脑卒中患者中的发生率为70-80%。虽然缺血型卒中可用组织型纤溶酶原激活剂进行治疗,但因其时间窗较狭窄,故脑缺血所造成的瘫痪、感觉减退、失语、吞咽不能、认知功能受损等功能障碍的发生率很高。神经组织再生可促进上述功能障碍的恢复。神经干细胞可参与受损神经系统的重建,在受损脑组织的自我修复过程中能促进神经功能的恢复。神经干细胞移植治疗缺血性卒中的研究已成为10多年的热点。综述讨论了神经干细胞治疗缺血性卒中的方法,以及其参与治疗作用的途径和机制。

orcid: 0000-0003-3603-749X (Qiang Gao)

关键词: 干细胞疗法, 神经干细胞, 细胞移植, 缺血性卒中, 脑缺血, 神经可塑性, 神经功能恢复, 神经再生

Abstract:

Cerebral ischemic injury is the main manifestation of stroke, and its incidence in stroke patients is 70–80%. Although ischemic stroke can be treated with tissue-type plasminogen activator, its time window of effec¬tiveness is narrow. Therefore, the incidence of paralysis, hypoesthesia, aphasia, dysphagia, and cognitive impairment caused by cerebral ischemia is high. Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction. Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue. Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years. This review discusses the treatment of ischemic stroke with neural stem cells, as well as the mechanisms of their involvement in stroke treatment.

Key words: nerve regeneration, stem cell therapy, neural stem cells, cell transplantation, ischemic stroke, cerebral ischemia, neuroplasticity, functional recovery, neural regeneration