中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (3): 208-217.doi: 10.3969/j.issn.1673-5374.2013.03.002

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

天麻联合抗癫痫药物修复局灶性癫痫的异常灌注灶

  

  • 收稿日期:2012-10-11 修回日期:2012-12-13 出版日期:2013-01-25 发布日期:2013-01-25

Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy

Weimin Wang, Zhenyu Fan, Yongqin Zhang, Yuxia Yang, Yaqing Liu, Xiaoli Dang, Wenjun Song, Yinping Wu, Jiang Ye   

  1. Epilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China
  • Received:2012-10-11 Revised:2012-12-13 Online:2013-01-25 Published:2013-01-25
  • Contact: Weimin Wang, Epilepsy Center, Second Hospital, Lanzhou University, Gansu Provincial Center for Prevention and Treatment of Epilepsy, Lanzhou 730030, Gansu Province, China, wwm5209@163.com.
  • About author:Weimin Wang, Professor, Chief physician, Master’s supervisor.
  • Supported by:

    This project was funded by the Key Project of Gansu Province, No. 2GS054-A43-014-19.

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摘要：

实验用抗癫痫药物口服控制100例局灶性癫痫患者癫痫临床发作，并进行抗癫痫药物血药浓度监测，随后采用全天麻胶囊口服治疗，于天麻治疗前、治疗12个月后分别进行脑部发作间期单光子CT、长程脑电图和CT/MRI检查。结果发现，治疗前100例患者中CT/MRI图像异常者占35例(35%)，SPECT图像异常者79例(79%)，异常灌注灶共146个。治疗后患者SPECT图像正常者增加12例(12.0%)，总异常灌注灶数减少52个(36%)，异常灶变化者65例(65%)；脑电图异常者86例(86%)，脑电图正常者增加27例(27%)，痫样放电者减少29例(34%)。说明中药天麻联合抗癫痫药修复局灶性癫痫患者异常灌注灶具有一定疗效，中药修复异常灌注灶可能成为治疗局灶性癫痫的新途径。

关键词: 神经再生, 脑损伤, 中医药, 天麻, 抗癫痫药, 联合修复, 局灶性癫痫, 异常灌注灶, 感兴趣区, 基金资助文章

Abstract:

One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroencephalogram, and CT/MRI. Blood drug levels were monitored throughout the study. Before treatment with tall gastrodis tuber, 35 of the 100 cases had abnormal CT/MRI scans; 79 cases had abnormal single photon emission computed tomography images; 86 cases had abnormal electroencephalogram; and a total of 146 abnormal perfusion foci were observed across the 100 subjects. After treatment, the number of patients with normal single photon emission computed tomography images increased by 12; normal electroencephalogram was observed in an additional 27 cases and the number of patients with epileptiform discharge decreased by 29 (34% of 86); the total number of abnormal perfusion foci decreased by 52 (36%) and changes in abnormal foci were visible in 65 patients. These changes indicate that the administration of tall gastrodis tuber in combination with antiepileptic drugs repairs abnormal perfusion foci in patients with focal epilepsy. Our results demonstrate that traditional Chinese drugs can repair abnormal perfusion foci and, as such, are a promising new pathway in the treatment of focal epilepsy.

Key words: neural regeneration, traditional Chinese medicine, neuroimaging, brain injury, tall gastrodis tuber, antiepileptic drugs, combination therapy, focal epilepsy, abnormal perfusion focus, single photon emission computed tomography, long-term vigilance-controlled electroencephalogram, region of interest, grant-supported paper, photographs-containing paper, neuoregeneration