Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson’s disease rats

doi:10.3969/j.issn.1673-5374.2013.06.007

Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (6): 540-545.doi: 10.3969/j.issn.1673-5374.2013.06.007

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Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson’s disease rats

Shuju Wang^{1, 2}, Jianqiao Fang¹, Jun Ma², Yanchun Wang², Shaorong Liang², Dan Zhou², Guojie Sun²

1 Department of Acupuncture and Moxibustion, Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
2 Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China

Received:2012-08-23 Revised:2012-11-20 Online:2013-02-25 Published:2013-02-25
Contact: Jianqiao Fang, M.D., Professor, Chief physician, Doctoral supervisor, Department of Acupuncture and Moxibustion, Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China, fangjianqiao@ yahoo.com.
About author:Shuju Wang☆, M.D. Associate professor.
Supported by:
This study was supported by the National Natural Science Foundation of China, No. 30973787, 30973809; the Open Research Fund of Zhejiang First-foremost Key Subject—Acupuncture & Moxibustion, No. ZTK2010A10; the Natural Science Foundation of Hubei Province, No. 2009CDA068; the Integrated Traditional and Western Medicine project by the Health Department of Hubei Province, No. 2010Z-Z01.

Abstract

Abstract:

Acupuncture for the treatment of Parkinson’s disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson’s disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson’s disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment. These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson’s disease. Thus, electroacupuncture may be useful in the treatment of Parkinson’s disease.

Key words: neural regeneration, acupuncture and moxibustion, neurodegenerative diseases, electroacupuncture, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, substantia nigra, rotenone, Parkinson’s disease, rats, reverse transcription-PCR, grants-supported paper, neuroregeneration

Shuju Wang, Jianqiao Fang, Jun Ma, Yanchun Wang, Shaorong Liang, Dan Zhou, Guojie Sun. Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson’s disease rats[J]. Neural Regeneration Research, 2013, 8(6): 540-545.

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Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson’s disease rats

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