中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (9): 809-816.doi: 10.3969/j.issn.1673-5374.2013.09.005

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

电针调解葡萄糖抑制性神经元治疗单纯性肥胖

  

  • 收稿日期:2012-07-27 修回日期:2013-01-14 出版日期:2013-03-25 发布日期:2013-03-25
  • 基金资助:

    国家重点基础研究发展计划（973计划，2011CB505206）；国家自然科学基金（NO.30873307，81202744）；江苏省高校自然科学研究计划项目（11KJB360008）；江苏省特色优势学科；江苏省高校青蓝工程优秀科技创新团队

Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity

Zhi Yu, Youbing Xia, Chuanhui Ju, Qinghua Shao, Zhen Mao, Yun Gu, Bin Xu   

  1. Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
  • Received:2012-07-27 Revised:2013-01-14 Online:2013-03-25 Published:2013-03-25
  • Contact: Bin Xu, Ph.D., Researcher, Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China, xuuuux@sina.com.
  • About author:Zhi Yu★, Master, Assistant.
  • Supported by:

    This study was supported by the National Basic Research Program of China (973 Program), No. 2011CB505206, the National Natural Science Foundation of China, No. 30873307 and No. 81202744; the Natural Science Research Project of Higher Education of Jiangsu Province, No. 11KJB360008; the Distinctive Discipline of Jiangsu Province; and the Scientific and Technological Innovation Group of “Qinglan Project” of Jiangsu Province.

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摘要：

分布在下丘脑外侧区的葡萄糖抑制性神经元为葡萄糖感受器，可通过感受胞外血糖浓度实现对摄食的调控，在肥胖的发病起着至关重要的作用。实验以电针刺激高脂饲养致肥胖模型大鼠左侧足三里/内庭和双侧天枢，结果发现电针刺激能有效减少肥胖大鼠体质量和脂体比，降低血清瘦素、抵抗素、肿瘤坏死因子α和神经肽Y水平，升高血清脂联素和八肽胆囊收缩素水平，影响下丘脑外侧区葡萄糖抑制性神经元的电活动，其中电针刺激“三里/内庭”以抑制作用为主，电针刺激“天枢/天枢”的效应可能有兴奋的倾向。提示电针下肢、腹部穴位通过调节下丘脑外侧区葡萄糖抑制性神经元的活动改善脂肪组织分泌功能。

关键词: 神经再生, 针灸, 电针, 穴位, 脂肪组织, 下丘脑, 肥胖, 摄食中枢, 中医, 针刺, 基金资助文章

Abstract:

The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations, and plays a crucial role in obesity onset. In the present study, obesity models established with high fat feeding were treated with electroacupuncture at Zusanli (ST36)/ Inner Court (ST44) on the left side and Tianshu (ST25) bilaterally. We found that electroacupuncture could effectively reduce body weight and the fat-weight ratio, and decrease serum leptin, resistin, tumor necrosis factor alpha, and neuropeptide Y levels, while increase serum adiponectin and cholecystokinin-8 levels. This treatment altered the electrical activity of glucose-inhibited neurons in the lateral hypothalamic area, with electroacupuncture at Zusanli/ Inner Court exerting an inhibitory effect, while electroacupuncture at bilateral Tianshu exerting an excitatory effect. These data suggest that electroacupuncture at the lower limbs and abdominal cavity is an effective means for regulating the activity of glucose-inhibited neurons in the lateral hypothalamic area and for improving the secretory function of adipose tissue.

Key words: neural regeneration, acupuncture and moxibustion, electroacupuncture, acupoint, adipose tissue, hypothalamus, obesity, feeding center, acupuncture, regeneration, grants-supported paper, neuroregeneration