中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (10): 930-937.doi: 10.3969/j.issn.1673-5374.2013.10.008

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

脑肿瘤的弥散张量成像与磁共振波谱成像：结构与代谢的关系

  

  • 收稿日期:2012-12-03 修回日期:2013-03-07 出版日期:2013-04-05 发布日期:2013-04-05

Diffusion tensor imaging and proton magnetic resonance spectroscopy in brain tumor  Correlation between structure and metabolism

Zhigang Min1, Chen Niu1, Netra Rana1, Huanmei Ji2, Ming Zhang1   

  1. 1 Department of Radiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
    2 Department of Radiology, Shaanxi Provincial Cancer Hospital, Xi’an 710061, Shaanxi Province, China
  • Received:2012-12-03 Revised:2013-03-07 Online:2013-04-05 Published:2013-04-05
  • Contact: Ming Zhang, M.D., Professor, Department of Radiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China, profzmmri@gmail.com.
  • About author:Zhigang Min☆, Studying for doctorate, Attending physician.
  • Supported by:

    (81171318)；陕西省科技攻关项目(2012K13-02-24)

PDF

971

摘要：

质子磁共振波谱和弥散张量成像分别是惟一的用于活体检测代谢和水分子扩散的无创性技术。以往研究发现脑胶质瘤患者的肿瘤、水肿及正常脑白质区域内的平均各向异性分数值和N-乙酰天门冬氨酸/肌酸、N-乙酰天门冬氨酸/胆碱有正相关性。实验根据磁共振常规扫描结果将脑肿瘤患者的脑实质分为肿瘤实质区、水肿区和正常脑实质区，分析各区的代谢产物和水分子扩散参数的相关性。结果发现，在正常脑实质内，N-乙酰天门冬氨酸和肌酸的比值不只与各向异性值有正相关性，且与最大本征值呈正相关性，与径向扩散系数呈负相关性；而在瘤周水肿区内，N-乙酰天门冬氨酸、胆碱、肌酸均与最大本征值、径向扩散系数呈的负相关；在肿瘤内则只有径向扩散系数与胆碱呈负相关性。说明从脑肿瘤患者正常脑白质区到瘤周水肿区和肿瘤区，代谢和结构的关系发生了很大变化，瘤周水肿区的神经代谢随着细胞外间隙扩大而降低，肿瘤实质内的神经功能与结构则失去正常的关联性。

关键词: 神经再生, 神经影像, 脑肿瘤, 磁共振波谱, 弥散张量成像, 代谢, 弥散, 各向异性, 水肿, 神经纤维, 细胞外间隙, 相关性分析, 基金资助文章

Abstract:

Proton magnetic resonance spectroscopy and diffusion tensor imaging are non-invasive techniques used to detect metabolites and water diffusion in vivo. Previous studies have confirmed a positive correlation of individual fractional anisotropy values with N-acetylaspartate/creatine and N-acetylaspartate/choline ratios in tumors, edema, and normal white matter. This study divided the brain parenchyma into tumor, peritumoral edema, and normal-appearing white matter according to MRI data, and analyzed the correlation of metabolites with water molecular diffusion. Results demonstrated that in normal-appearing white matter, N-acetylaspartate/creatine ratios were positively correlated with fractional anisotropy values, negatively correlated with radial diffusivities, and positively correlated with maximum eigenvalues. Maximum eigenvalues and radial diffusivities in peritumoral edema showed a negative correlation with choline, N-acetylaspartate, and creatine. Radial diffusivities in tumor demonstrated a negative correlation with choline. These data suggest that the relationship between metabolism and structure is markedly changed from normal white matter to peritumoral edema and tumor. Neural metabolism in the peritumoral edema area decreased with expanding extracellular space. The normal relationship of neural function and microstructure disappeared in the tumor region.

Key words: neural regeneration, neuroimaging, brain neoplasms, magnetic resonance spectroscopy, diffusion tensor imaging, metabolism, diffusion, anisotropy, edema, nerve fiber, extracellular space, correlation analysis, grants-supported paper, neuroregeneration