中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (14): 1337-1342.doi: 10.3969/j.issn.1673-5374.2013.14.010

• 原著:周围神经损伤修复保护与再生 • 上一篇    

个体易感性是三叉神经痛发病的潜在危险因素

  

  • 收稿日期:2012-10-24 修回日期:2013-03-07 出版日期:2013-05-15 发布日期:2013-05-15

Differences in individual susceptibility affect the development of trigeminal neuralgia

Yusuf Kurtuluş Duransoy1, Mesut Mete1, Emrah Akçay2, Mehmet Selçuki1   

  1. 1 Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey
    2 Clinic of Neurosurgery, Anamur State Hospital, Mersin, Turkey
  • Received:2012-10-24 Revised:2013-03-07 Online:2013-05-15 Published:2013-05-15
  • Contact: Yusuf Kurtulu? Duransoy☆, M.D., Assistant professor, Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey, ykduransoy@hotmail.com.

摘要:

三叉神经痛是一种颅神经功能超强综合征,以一侧面部三叉神经分布区内反复发作的阵发性剧烈痛为主要表现,一般认为三叉神经痛的发生是由于血管在神经根上形成压迹或引起神经根扭曲变形。文章报道了4例在开颅治疗后,未知原因引起的三叉神经痛病例。我们实施的外科干预与三叉神经无关,说明三叉神经痛的发病存在个体易感性。开颅后,神经与血管结构的接触和脑脊液流量的改变可能是导致他们发生三叉神经痛的原因。

关键词: 神经再生, 周围神经损伤, 临床实践, 颅神经的无症状血管压迫, 颅神经敏感性, 三叉神经根入桥脑处, 三叉神经根出桥脑处, 病因, 颅神经功能超强综合征, 个体易感性, 危险因素

Abstract:

Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve, and is characterized by a sudden, usually unilateral, recurrent lancinating pain arising from one or more divisions of the nerve. The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course. In this paper, we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention. The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility, nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain.

Key words: neural regeneration, peripheral nerve injury, asymptomatic vascular compression of the cranial nerves, cranial nerves, dorsal root entry zone, dorsal root exit zone, etiology, hyperactive dysfunction syndrome, individual susceptibility, risk factors, trigeminal neuralgia, neuroregeneration