中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (21): 1958-1965.doi: 10.3969/j.issn.1673-5374.2013.21.004
复发缓解性多发性硬化患者大脑灰质区域性萎缩与认知和情绪异常
Regional gray matter atrophy and neuropsychological problems in relapsing-remitting multiple sclerosis
Aiyu Lin1, Fuyong Chen2, Fang Liu3, Zhiwen Li1, Ying Liu4, Shifang Lin1, Xiaoyi Wang2, Jiting Zhu1
- 1 Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
2 Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
3 Department of Hyperbaric Oxygen Treatment, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
4 Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
摘要：
多发性硬化患者常出现广泛的大脑灰质萎缩，且经常出现认知与心理障碍，有人推测局灶性萎缩与后续神经心理功能降低有关，常规MRI检测到的病理特征无法对其进行充分的解释，且临床上孤立综合征及确诊的多发性硬化患者中没有发现认知障碍和常规MRI测量结果之间的关联性。实验以基于体素的核磁共振形态学研究方法精确测量11例中国复发缓解性多发性硬化患者大脑灰质的萎缩，结果证实复发缓解性多发性硬化患者存在大脑灰质萎缩，且发现多发性硬化患者右侧额叶上中回灰质萎缩与汉密尔顿焦虑评定量表评分存在明显相关性；反映的认知能力可重复的成套神经心理状态测量评分与左侧额叶中回、右侧额叶上中回、左侧扣带中回、左侧额叶上中回、左侧额叶三角区灰质萎缩存在联系，但没有统计学意义。提示大脑萎缩最显著的区域优势半球扣带和额叶皮质灰质萎缩，可能与患者认知能力下降和情绪异常有关。