中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (22): 2069-2077.doi: 10.3969/j.issn.1673-5374.2013.22.006

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

合募配穴电针调节内脏高敏感大鼠脊髓和结肠P2X4受体

  

  • 收稿日期:2013-04-24 修回日期:2013-07-08 出版日期:2013-08-05 发布日期:2013-08-05

Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity

Xinxin Guo1, Jifei Chen2, Yuan Lu3, Luyi Wu3, Zhijun Weng3, Ling Yang3, Yuhu Xin4,Xianming Lin1, Yi Liang1, Jianqiao Fang1   

  1. 1 Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
    2 Department of Orthopedics, Zhongshan Hospital of Fudan University, Shanghai 200032, China
    3 Shanghai Institute for Traditional Chinese Medicine, Shanghai 201203, China
    4 Cancer Hospital, Fudan University, Shanghai 200032, China
  • Received:2013-04-24 Revised:2013-07-08 Online:2013-08-05 Published:2013-08-05
  • Contact: Jianqiao Fang, M.D.,Professor, Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China, fangjianqiao@yahoo.com.cn.
  • About author:Xinxin Guo, Master. Xinxin Guo, Jifei Chen, and Yuan Lu contributed equally to this article.

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摘要：

电针可通过刺激“上巨虚”穴、“天枢”穴来改善大鼠内脏高敏感。实验采用结直肠球囊扩张法制备大鼠肠易激综合征慢性内脏高敏感模型。发现该模型大鼠腹部撤回反射评分显著增高，同时结肠和脊髓P2X4受体免疫阳性反应明显升高。电针及匹维溴铵治疗可明显降低内脏高敏感大鼠腹部撤回反射评分，同时结肠和脊髓P2X4受体免疫阳性反应显著降低。提示电针治疗可能通过降低结肠和脊髓中P2X4受体的免疫阳性反应来降低肠易激综合征大鼠的内脏高敏感。

关键词: 神经再生, 中医药, 合募配穴, 电针, 肠易激综合征, 内脏高敏感, P2X4受体, 针灸, 基金资助文章