中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (27): 2566-2572.doi: 10.3969/j.issn.1673-5374.2013.27.008

• 原著:退行性病与再生 • 上一篇    下一篇

低频重复经颅磁刺激对慢性癫痫模型大鼠脑电非线性参数的影响

  

  • 收稿日期:2013-05-08 修回日期:2013-08-01 出版日期:2013-09-25 发布日期:2013-09-25

Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure

Yinxu Wang, Xiaoming Wang, Sha Ke, Juan Tan, Litian Hu, Yaodan Zhang, Wenjuan Cui   

  1. Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
  • Received:2013-05-08 Revised:2013-08-01 Online:2013-09-25 Published:2013-09-25
  • Contact: Xiaoming Wang, Master, Professor, Master’s supervisor, Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China, wangxm238@163.com.
  • About author:Yinxu Wang, Master, Researcher.
  • Supported by:

    This study was supported by the Key Project of Sichuan Provincial Education Department, No. (2010) 597.

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摘要：

重复经颅磁刺激作为一种新兴的神经调控技术，具有潜在的抗癫痫作用，有望成为难治性癫痫的有效治疗手段，但其机制尚待阐清。实验观察低频重复经颅磁刺激对慢性癫痫模型大鼠脑电非线性参数的影响，探讨其抗癫痫可能的电生理机制。实验组和模型组大鼠制作氯化锂-匹鲁卡品慢性癫痫大鼠模型，33d后实验组大鼠开始接受重复经颅磁刺激治疗，0.5HZ、40%运动阈值、100次/串、5串/d、串间隔30秒，连续7d。于刺激后7，14，28d采集大鼠的脑电信号，分析脑电非线性参数值关联维数（D2）、点关联维数（PD2）、李亚普诺夫指数（LE）、柯尔莫哥罗夫熵（KE）、复杂度（Cx）、近似熵（ApEn）的变化。结果显示，实验组、模型组脑电非线性参数D2、PD2、LE、KE值均低于对照组，差异具有统计学意义，CX、ApEn值与对照组比较无统计学差异；实验组D2、KE值低于模型组，差异具有统计学意义；低频重复经颅磁刺激后28d，实验组PD2、CX值低于模型组，差异具有统计学意义，低频重复经颅磁刺激后7,14d与模型组比较差异无统计学意义；实验组LE、ApEn值与模型组比较差异无统计学意义。实验结果说明低频重复经颅磁刺激对癫痫大鼠脑电活动有一定的抑制作用，其抗癫痫机制可能与这种抑制作用有关。

关键词: 神经再生, 神经影像, 重复经颅磁刺激, 脑电图, 非线性分析, 非线性参数, 癫痫, 痫性发作, 痫样放电, 基金资助文章

Abstract:

Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroenceph-alographic parameters in rats with chronic epilepsy and explored the mechanism underlying repeti-tive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was estab-lished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear elec-electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.

Key words: neural regeneration, repetitive transcranial magnetic stimulation, electroencephalogram, nonlinear analysis, nonlinear parameters, epilepsy, epileptic seizure, epileptic discharge, grant-supported paper, neuroregeneration