中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (27): 2557-2565.doi: 10.3969/j.issn.1673-5374.2013.27.007

• 原著:退行性病与再生 • 上一篇    下一篇

帕金森病患者脑灰质体积缺失区域磁共振的形态学分析

  

  • 收稿日期:2013-03-06 修回日期:2013-03-06 出版日期:2013-09-25 发布日期:2013-09-25
  • 基金资助:

    南通大学自然科学基金（11Z001）；江苏省自然科学基金（BK2008010）

Magnetic resonance morphometry of the loss of gray matter volume in Parkinson’s disease patients

Jianguo Xia1, Juan Wang2, Weizhong Tian1, Hongbin Ding1, Qilin Wei3, Huanxin Huang3, Jun Wang3, Jinli Zhao4, Hongmei Gu4, Lemin Tang2   

  1. 1 Department of Radiology, Taizhou People’s Hospital of Nantong University, Nantong 225300, Jiangsu Province, China

    2 Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China

    3 Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China

    4 Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
  • Received:2013-03-06 Revised:2013-03-06 Online:2013-09-25 Published:2013-09-25
  • Contact: Lemin Tang, Master, Professor, Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China, lemint50@ntu.edu.cn.
  • About author:Jianguo Xia, Master, Attending physician. Jianguo Xia and Juan Wang contributed equally to this work.
  • Supported by:

    This work was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the Medical Clinical Science and Technology Developemnt Fund of Jiangsu University, No. JLY20120122; Innovative Climb Program of Natural Science Foundation of Jiangsu Province, No. BK2008010; and the Natural Science Foundation of Nantong University, No.11Z001

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摘要：

基于体素的形态学测量技术可以定量比较受试者全脑灰质结构的差异及功能改变。鉴于此，实验采用3.0T高场强磁共振高分辨三维T1WI成像，同时结合受试者临床神经量表得分情况，运用基于体素的形态学分析方法对32例帕金森病患者及25例健康对照组的大脑灰质图像进行比较。结果发现，与健康对照组相比，帕金森病患者简易智力状况检查量表、蒙特利尔认知评定量表得分明显降低，其中帕金森病患者蒙特利尔认知评定量表中子项视空间与执行功能得分降低明显，非运动症状均分明显升高。帕金森病患者的脑灰质体积较健康对照组广泛减少，这些区域包括双侧颞叶、枕叶、顶叶、额叶、岛叶、海马旁回、杏仁核、右侧钩回及右侧小脑后叶等。结果显示，基于体素的形态学分析方法能较全面、准确、定量地表现帕金森病患者广泛存在的脑灰质体积缺失区域，可以为帕金森病患者的多系统受累的病理机制提供必要的神经影像学依据。

关键词: 神经再生, 神经影像, 神经退行性变, 基于体素的形态学测量, 帕金森病, 磁共振成像, 多巴胺, 非运动症状, 灰质异常, 感兴趣区, 简易智力状况检查量表, 蒙特利尔认知评定量表, 神经退行性病变, 基金资助文章

Abstract:

Voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson’s disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson’s dis-ease. In addition, gray matter volume was significantly diminished in Parkinson’s disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebellum. These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson's disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson’s disease.

Key words: neural regeneration, neuroimaging, neurodegeneration, voxel-based morphometry, Parkinson’s disease, MRI, dopamine, non-motor symptoms, gray matter abnormality, region of interest, Mini-Mental State Examination, Montreal Cognitive Assessment, neurodegenerative disease, grants-supported paper, neuroregeneration