中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (6): 610-615.doi: 10.4103/1673-5374.130103

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

自体静脉修复胫神经缺损后肌梭内感觉神经的再支配

  

  • 收稿日期:2014-02-12 出版日期:2014-03-22 发布日期:2014-03-22
  • 基金资助:

    2013年解放军南京军区医学科学与技术基金项目(ZX22)

Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

Youwang Pang, Qingnan Hong, Jinan Zheng   

  1. Department of Orthopedics, the 180 Hospital of Chinese PLA, Quanzhou, Fujian Province, China
  • Received:2014-02-12 Online:2014-03-22 Published:2014-03-22
  • Contact: Jinan Zheng, M.D., Department of Orthopedics, the 180 Hospital of Chinese PLA, Quanzhou 362000, Fujian Province, China, zhengjinan@sina.com.
  • Supported by:

    This work was supported by the Medical Science and Technology Innovation Foundation of Nanjing Military Area Command of Chinese PLA in 2013, ZX22.

摘要:

既往研究已经证实大鼠自体静脉桥接神经缺损可以实现运动神经的再支配,但是否能实现感觉神经再支配尚不清楚。实验结果显示静脉桥接和神经端直接吻合修复10mm胫神经缺损的大鼠腓肠肌均有部分肌梭实现了感觉神经再支配,而且电生理检查也证实了部分功能的恢复,两种方法修复的大鼠腓肠肌无论是肌梭长度和直径方面还是电生理结果方面均无明显差异。因此作者认为通过自体静脉桥接短距离神经缺损在改善肌梭感觉神经再支配方面可以达到和神经端端吻合一样的效果。

关键词: 神经再生, 周围神经损伤, 肌梭, 静脉, 胫神经, 腓肠肌, 神经丝蛋白H

Abstract:

Motor reinnervation after repair of tibial nerve defects using autologous vein grafts in rats has previously been reported, but sensory reinnervation after the same repair has not been fully investigated. In this study, partial sensory reinnervation of muscle spindles was observed after repair of 10-mm left tibial nerve defects using autologous vein grafts with end-to-end anastomosis in rats, and functional recovery was confirmed by electrophysiological studies. There were no significant differences in the number, size, or electrophysiological function of reinnervated muscle spindles between the two experimental groups. These findings suggest that repair of short nerve defects with autologous vein grafts provides comparable results to immediate end-to-end anastomosis in terms of sensory reinnervation of muscle spindles.

Key words: nerve regeneration, peripheral nerve injury, muscle spindle, vein, tibial nerve, gastrocnemius muscle, neurofilament protein H, neural regeneration