Botulinum toxin type A is a potent muscle relaxant that blocks the transmission and release of acetylcholine at the neuromuscular junction. Intramuscular injection of botulinum toxin type A has served as an effective and safe therapy for strabismus and focal dystonia. However, muscular weakness is temporary and after 3–4 months, muscle strength usually recovers because functional recovery is mediated by nerve sprouting and reconstruction of the neuromuscular junction. Acrylamide may produce neurotoxic substances that cause retrograde necrotizing neuropathy and inhibit nerve sprouting caused by botulinum toxin type A. Hong Jiang and co-workers from Sir Run Run Shaw Hospital of Zhejiang University in China investigated whether 3% acrylamide inhibits nerve sprouting after intramuscular injection of botulinum toxin type A (5 U) into the right gastrocnemius. Following intraperitoneal injection of acrylamide, the peak muscle fiber density decreased, and the maximal decrease in fiber density and the time at which functional conduction of neuromuscular junction was restored were delayed. Additionally, the increase in tibial nerve fibers was reduced, indicating acrylamide inhibits nerve sprouting caused by botulinum toxin type A and may be used to prolong the clinical dosage of botulinum toxin type A. This relevant article has been reported in the Neural Regeneration Research (Vol. 9, No. 16, 2014).
Article: " Acrylamide inhibits nerve sprouting induced by botulinum toxin type A," by Hong Jiang1, Yi Xiang2, Xingyue Hu1, Huaying Cai1 (1 Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China 2 Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China)
Jiang H, Xiang Y, Hu XY, Cai HY. Acrylamide inhibits nerve sprouting induced by botulinum toxin type A. Neural Regen Res. 2014;9(16):1525-1531.
Contact: Meng Zhao
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