中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (17): 1621-1627.doi: 10.4103/1673-5374.141791

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

传统中药补阳还五汤对脑缺血损伤神经元的保护效应

  

  • 收稿日期:2014-08-04 出版日期:2014-09-16 发布日期:2014-09-16

Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage

Qingchun Mu 1, 2, Pengfei Liu 1, Xitong Hu 1, Haijun Gao 1, Xu Zheng 1, Haiyan Huang 1   

  1. 1 First Hospital of Bethune, Jilin University, Changchun, Jilin Province, China
    2 Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China
  • Received:2014-08-04 Online:2014-09-16 Published:2014-09-16
  • Contact: Haiyan Huang, M.D., Ph.D., First Hospital of Bethune, Jilin University, Changchun 130021, Jilin Province, China, Huanghy@jlu.edu.cn.
  • Supported by:

    This work was supported by grants from Health and Family Planning Commission of Heilongjiang Province Research Projects, No. 2014-195 and Science and Technology Research Projects of Mudanjiang Medical University, No. ZS201305.

摘要:

在众多治疗脑卒中的方法中,传统中药的作用越来越受到广泛关注。补阳还五汤是治疗脑缺血的典型传统药物。文章综述了由黄芪、当归尾、赤芍、川芎、红花、桃仁、地龙共7味中药组成的经典方剂补阳还五汤活性成分、干预靶点及在脑缺血治疗中的应用。从而为补阳还五汤在脑缺血治疗中的神经保护效应提供合理、有效的应用信息。

关键词: 神经再生, 补阳还五汤, 中医药, 脑缺血, 临床应用, 神经保护, 综述

Abstract:

Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix Astragali seu Hedysari), Danggui (Radix Angelica sinensis), Chishao (Radix Paeoniae Rubra), Chuanxiong (Rhizoma Ligustici Chuanxiong), Honghua (Flos Carthami), Taoren (Semen Persicae) and Dilong (Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction.

Key words: nerve regeneration, Buyang Huanwu decoction, traditional Chinese medicine, cerebral ischemia, clinical application, neuroprotection, review, neural regeneration