中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (21): 1884-1890.doi: 10.4103/1673-5374.145353

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

丁香醛保护大鼠脑缺血损伤:抗氧化及抗凋亡效应验证

  

  • 收稿日期:2014-09-06 出版日期:2014-11-15 发布日期:2014-11-15

Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties

Aras Adem Bozkurt 1, Guven Mustafa 1, Akman Tarık 1, Ozkan Adile 2, Sen Halil Murat 2, Kılıcoglu Mesut 3, Kalkan Yıldıray 4, Silan Coskun 5, Cosar Murat 1   

  1. 1 Department of Neurosurgery, Çanakkale Onsekiz Mart University, Canakkale, Turkey
    2 Department of Neurology, Çanakkale Onsekiz Mart University, Canakkale, Turkey
    3 Department of Medical Biochemistry, Ondokuz May?s University, Samsun, Turkey
    4 Deparment of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdo?an University, Rize, Turkey
    5 Department of Pharmacology, Çanakkale Onsekiz Mart University, Canakkale, Turkey 
  • Received:2014-09-06 Online:2014-11-15 Published:2014-11-15
  • Contact: Aras Adem Bozkurt, Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey, guven2340@hotmail.com.

摘要:

目前,尚未见丁香醛对脑缺血大鼠模型神经保护作用的报道。我们假设丁香醛的抗氧化和抗炎作用将对缺血脑细胞产生保护作用。实验设计给予脑缺血大鼠腹腔注射丁香醛进行干预。结果发现给药后6和24h,脑缺血大鼠缺血大脑细胞病理损害明显减轻,脑组织SOD活力和NRF1水平明显升高,MDA水平明显下降,凋亡相关半胱氨酸肽酶caspase-3和-9免疫活性明显降低,神经功能明显改善。说明丁香醛通过抗氧化、抗凋亡途径对大鼠脑缺血损伤起神经保护作用。
 

关键词: 神经再生, 丁香醛, 脑缺血, 神经保护, 抗炎, 抗氧化, 凋亡

Abstract:

There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.

Key words: nerve regeneration, syringaldehyde, brain ischemia, neuroprotective effects, inflammatory, oxidative stress, apoptosis, neural regeneration