中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1860-1864.doi: 10.4103/1673-5374.170317

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

弥散张量成像评定椎管狭窄腰骶部脊神经根损伤的程度

  

  • 收稿日期:2015-09-10 出版日期:2015-12-07 发布日期:2015-12-07
  • 基金资助:

    广东省2012年科技发展项目(2012B031800232)

Changes in lumbosacral spinal nerve roots on diffusion tensor imaging in spinal stenosis

Zhong-jun Hou1, *, Yong Huang1, Zi-wen Fan2, Xin-chun Li3, Bing-yi Cao1   

  1. 1 Department of Radiology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
    2 Department of Orthopedics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
    3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
  • Received:2015-09-10 Online:2015-12-07 Published:2015-12-07
  • Contact: Zhong-jun Hou, 13694208683@163.com.
  • Supported by:

    This study was supported by the Science and Technology Planning Project of Guangdong Province of China in 2012, No. 2012B031800232.

摘要:

弥散张量成像已用于中枢神经系统白质神经纤维束的成像,也可显示周围神经纤维。为此,试验应用T2WI 检测到腰椎管狭窄患者L3-S1狭窄椎间盘残存的硬脊膜面积小于正常轴向面积的2/3。T1WI及T2WI显示20例椎管狭窄患者中74条腰骶神经根显示压迫,经弥散张量成像验证了T1WI及T2WI的结果:其中36条(49%)出现细化和扭曲,17条(23%)出现破裂,且腰骶部狭窄患者腰骶神经根的各项异性值降低。说明弥散张量成像可客观量化评价因腰椎管狭窄损伤腰骶神经根的程度。

关键词: 神经再生, 磁共振成像, 弥散张量成像, 腰骶部, 退行性变, 神经根, 各项异性

Abstract:

Lumbosacral degenerative disc disease is a common cause of lower back and leg pain. Conventional T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI) scans are commonly used to image spinal cord degeneration. However, these modalities are unable to image the entire lumbosacral spinal nerve roots. Thus, in the present study, we assessed the potential of diffusion tensor imaging (DTI) for quantitative assessment of compressed lumbosacral spinal nerve roots. Subjects were 20 young healthy volunteers and 31 patients with lumbosacral stenosis. T2WI showed that the residual dural sac area was less than two-thirds that of the corresponding normal area in patients from L3 to S1 stenosis. On T1WI and T2WI, 74 lumbosacral spinal nerve roots from 31 patients showed compression changes. DTI showed thinning and distortion in 36 lumbosacral spinal nerve roots (49%) and abruption in 17 lumbosacral spinal nerve roots (23%). Moreover, fractional anisotropy values were reduced in the lumbosacral spinal nerve roots of patients with lumbosacral stenosis. These findings suggest that DTI can objectively and quantitatively evaluate the severity of lumbosacral spinal nerve root compression.

Key words: nerve regeneration, magnetic resonance imaging, diffusion tensor imaging, lumbosacral area, degeneration, nerve root, fractional anisotropy, neural regeneration