中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (1): 174-179.doi: 10.4103/1673-5374.175067

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

引人注目的血管内皮生长因子:缺氧缺血性脑损伤干预靶点

  

  • 收稿日期:2015-10-12 出版日期:2016-01-15 发布日期:2016-01-15
  • 基金资助:

    国家自然科学基金(81401238, 81330016, 31171020, 81172174, 81270724);国家教育部基金(313037, 20110181130002);国家科技部基金(2012BAI04B04);四川省科技局基金(2012SZ0010, 2014FZ0113,2014SZ0149);国家卫生部基金(1311200003303)

Vascular endothelial growth factor: an attractive target in the treatment of hypoxic/ischemic brain injury

Hui Guo 1, 2, Hui Zhou 1, 2, Jie Lu 3, Yi Qu 1, 2, Dan Yu 1, 2, Yu Tong 1, 2   

  1. 1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
    2 Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
    3 Department of Medical Cosmetology, Chengdu Second People’s Hospital, Chengdu, Sichuan Province, China
  • Received:2015-10-12 Online:2016-01-15 Published:2016-01-15
  • Contact: Yu Tong or Dan Yu,zisu_yu@163.com or yd540@126.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81401238, 81330016, 31171020, 81172174 and 81270724; the grants from Ministry of Education of China, No. 313037, 20110181130002; a grant from State Commission of Science Technology of China, No. 2012BAI04B04; the grants from Science and Technology Bureau of Sichuan Province of China, No. 2012SZ0010, 2014FZ0113, 2014SZ0149; and a grant from Clinical Discipline Program (Neonatology) from the Ministry of Health of China, No. 1311200003303.

摘要:

脑缺氧缺血引起一系列损伤,如细胞死亡、脑水肿和其他细胞反应,如血管生成和功能性血管结构的重建。研究已证实缺氧缺血性脑损伤后,血管内皮生长因子表达于中枢神经系统,且通过调节血管生成、神经发生和神经突生长、脑水肿,参与脑细胞修复。文章综述了血管内皮生长因子及与缺氧缺血性脑损伤相关的信号通路,以期找到缺氧缺血损伤干预的更有效措施。

关键词: 神经再生, 脑损伤, 缺氧缺血性脑损伤, 血管内皮生长因子, 血管内皮生长因子受体, 缺氧诱导因子1, PI3K/Akt信号通路, Akt/eNOS信号通路, JAK/STAT, Src-SSeCKS信号通路

Abstract:

Cerebral hypoxia or ischemia results in cell death and cerebral edema, as well as other cellular reactions such as angiogenesis and the reestablishment of functional microvasculature to promote recovery from brain injury. Vascular endothelial growth factor is expressed in the central nervous system after hypoxic/ischemic brain injury, and is involved in the process of brain repair via the regulation of angiogenesis, neurogenesis, neurite outgrowth, and cerebral edema, which all require vascular endothelial growth factor signaling. In this review, we focus on the role of the vascular endothelial growth factor signaling pathway in the response to hypoxic/ischemic brain injury, and discuss potential therapeutic interventions.

Key words: nerve regeneration, VEGF, VEGFR, HIF1, PI3K/Akt pathway, Akt/eNOS pathway, JAK/STAT, Src-SSeCKS pathway, hypoxic/ischemic brain injury, neural regeneration