中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (2): 257-261.doi: 10.4103/1673-5374.177733

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

轻度颅脑创伤患者脑血流的有效检测方法

  

  • 收稿日期:2015-11-25 出版日期:2016-02-15 发布日期:2016-02-15

Pulsed arterial spin labeling effectively and dynamically observes changes in cerebral blood flow after mild traumatic brain injury

Shu-ping Peng 1, Yi-ning Li 1, Jun Liu 1, Zhi-yuan Wang 2, Zi-shu Zhang 1, Shun-ke Zhou 1, Fang-xu Tao 1, Zhi-xue Zhang 1   

  1. 1 Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
    2 Hunan Cancer Hospital, Changsha, Hunan Province, China
  • Received:2015-11-25 Online:2016-02-15 Published:2016-02-15
  • Contact: Jun Liu, M.D.,2322349829@qq.com.

摘要:

脑血流与脑组织功能密切相关,是多种脑病的主要症状和诊断依据,但轻度颅脑外伤发生后,脑血流变化情况目前尚无共识标准。因此我们拟采用磁共振脉冲式动脉自旋标记序列动态观察轻度颅脑外伤患者不同脑区脑血流的变化。发现轻度颅脑外伤患者脑灰质脑血流值最大,白质最小;急性期和亚急性期枕叶、顶叶、中央区、皮下区及额叶脑血流明显下降,慢性期脑血流有所恢复,急性期,亚急性及慢性期脑岛叶血流变化不明显;急性及亚急性期颞叶及边缘叶脑血流下降,慢性期有所恢复。说明脉冲式动脉自旋标记序列可以准确测量各脑区脑血流,对创伤性颅脑损伤病情评估及预后判断起到一定的参考作用。

关键词: 神经再生, MRI, 脉冲式动脉自旋标记序列, 脑血流, 轻度颅脑外伤, Glasgow评分, 白质, 灰质, CT

Abstract:

Cerebral blood flow is strongly associated with brain function, and is the main symptom and diagnostic basis for a variety of encephalopathies.
However, changes in cerebral blood flow after mild traumatic brain injury remain poorly understood. This study sought to observe changes in cerebral blood flow in different regions after mild traumatic brain injury using pulsed arterial spin labeling. Our results demonstrate maximal cerebral blood flow in gray matter and minimal in the white matter of patients with mild traumatic brain injury. At the acute and subacute stages, cerebral blood flow was reduced in the occipital lobe, parietal lobe, central region, subcutaneous region, and frontal lobe. Cerebral blood flow was restored at the chronic stage. At the acute, subacute, and chronic stages, changes in cerebral blood flow were not apparent in the insula. Cerebral blood flow in the temporal lobe and limbic lobe diminished at the acute and subacute stages, but was restored at the chronic stage. These findings suggest that pulsed arterial spin labeling can precisely measure cerebral blood flow in various brain regions, and may play a reference role in evaluating a patient’s condition and judging prognosis after traumatic brain injury.

Key words: nerve regeneration, MRI, pulsed arterial spin labeling technique, cerebral blood flow, mild traumatic brain injury, Glasgow Coma Scale, white matter, gray matter, CT, neural regeneration