中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (5): 801-806.doi: 10.4103/1673-5374.182708

• 原著:退行性病与再生 • 上一篇    下一篇

高频电针干预可更明显的增强阿尔茨海默病大鼠海马突触传递功能

  

  • 收稿日期:2016-03-07 出版日期:2016-05-20 发布日期:2016-05-20
  • 基金资助:

    国家自然科学基金(81373741)

High-frequency electroacupuncture evidently reinforces hippocampal synaptic transmission in Alzheimer’s disease rats

Wei Li1, Li-hong Kong2, *, Hui Wang1, Feng Shen2, Ya-wen Wang2, Hua Zhou2, Guo-jie Sun2   

  1. "1 Hubei University of Chinese Medicine, Wuhan, Hubei Province, China 2 School of Acupuncture Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei Province, China"
  • Received:2016-03-07 Online:2016-05-20 Published:2016-05-20
  • Contact: Li-hong Kong, xiyu1618@sina.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81373741.

摘要:

目前比较公认的电针治疗阿尔茨海默病的频率范围是2-5Hz(低频)和50-100Hz(高频),为验证哪种频率更适合治疗阿尔茨海默病,实验以双侧海马齿状回注射Aβ1-42构建阿尔茨海默病模型大鼠,采用2Hz或50Hz频率电针刺激大鼠百会和肾俞。以水迷宫试验和电生理检测发现,阿尔茨海默病大鼠经电针治疗后空间记忆能力明显改善,海马长时程增强和长时程抑制幅度升高,且50Hz的效果优于2Hz。表明高频电针效果更明显的增强阿尔茨海默病大鼠海马突触传递功能,改善记忆障碍。

orcid: 0000-0002-4287-0536(Li-hong Kong)

关键词: 神经再生, 阿尔茨海默病, 频率, 电针, 长时程增强, 长时程抑制, 学习记忆, 百会穴, 肾俞穴

Abstract:

"The frequency range of electroacupuncture in treatment of Alzheimer’s disease in rats is commonly 2–5 Hz (low frequency) and 50–100 Hz (high frequency). We established a rat model of Alzheimer’s disease by injecting β-amyloid 1–42 (Aβ1–42) into the bilateral hippocampal dentate gyrus to verify which frequency may be better suited in treatment. Electroacupuncture at 2 Hz or 50 Hz was used to stimulate Baihui (DU20) and Shenshu (BL23) acupoints. The water maze test and electrophysiological studies demonstrated that spatial memory ability was apparently improved, and the ranges of long-term potentiation and long-term depression were increased in Alzheimer’s disease rats after electroacupuncture treatment. Moreover, the effects of electroacupuncture at 50 Hz were better than that at 2 Hz. These findings suggest that high-frequency electroacupuncture may enhance hippocampal synaptic transmission and potentially improve memory disorders in Alzheimer’s disease rats."

Key words: nerve regeneration, Alzheimer’s disease, frequency, electroacupuncture, long-term potentiation, long-term depression, learning and memory, Baihui (DU20), Shenshu (BL23), neural regeneration