中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (12): 2035-2044.doi: 10.4103/1673-5374.221161

• 原著:退行性病与再生 • 上一篇    下一篇

多尺度建模技术验证特发性震颤的中枢震荡信号传递途径

  

  • 收稿日期:2017-11-05 出版日期:2017-12-15 发布日期:2017-12-15
  • 基金资助:

    国家自然科学基金（61361160415, 81271684, 81501570）；国家重点基础研究发展（973计划），（2011cb013304）；上海交通大学医学工程学科的研究项目（yg2014zd09号）；中国的高等院校上海青年学者东部计划机构项目（qd2015007）

Neural computational modeling reveals a major role of corticospinal gating of central oscillations in the generation of essential tremor

Hong-en Qu1, Chuanxin M. Niu1, 2, Si Li1, Man-zhao Hao1, Zi-xiang Hu1, Qing Xie2, Ning Lan1, 3   

  1. 1 Laboratory of Neurorehabilitation Engineering, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
    2 Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    3 Division of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA
  • Received:2017-11-05 Online:2017-12-15 Published:2017-12-15
  • Contact: Ning Lan, Ph.D. or Qing Xie,M.D., ninglan@sjtu.edu.cn or ruijin_xq@163.com.
  • Supported by:

    This work was supported in part by the National Natural Science Foundation of China, No. 61361160415, 81271684, 81501570; the Major State Basic Research Development of China (973 Program), No. 2011CB013304; the Medicine-Engineering Interdisciplinary Research Grant from Shanghai Jiao Tong University in China, No. YG2014ZD09; and a grant from the Youth Eastern Scholar Program at Shanghai Institutions of Higher Learning in China, No. QD2015007.

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摘要：

特发性震颤（essential tremor，ET)，又称为家族性震颤，一般认为此病为常染色体显性遗传病，是一种最常见的运动障碍性疾病，主要为手、头部及身体其他部位的姿位性和运动性震颤。研究证明特发性震颤是由脑部的中枢震荡信号造成，然而造成特发性震颤的皮质—脊髓机制却仍不清楚。实验针对这一问题建立了一个神经计算模型，模型包括了单突触和多突触皮质脊髓通路，这些通路可以与固有神经元网络互动。模型还包括一个虚拟手臂，能够以中枢震荡信号来模拟震颤行为。基于中枢震荡信号通过下行通路传递到脊髓运动神经元的基本原理，实验仿真了模拟若干种不同情况，即中枢震荡信号分别承载于α运动神经元单突触通路，α运动神经元多突触通路，静态γ 神经元以及动态γ运动神经元。实验对仿真行为与真实特发性震颤的特征数据进行了比较，鉴别出能够传递中枢震荡信号的皮质-脊髓通路。考虑到固有神经元对皮质有较强的抑制能力，因而此通路可以实现对于特发性震颤的选通作用。实验的结果证实了特发性震颤的中枢震荡信号可通过皮质-脊髓神经通路进行传递，固有神经元网络对于中继中枢震荡信号具有重要作用。

orcid:0000-0001-6061-5419(Ning Lan)
0000-0002-3298-1072(Qing Xie)

关键词: 神经再生, 神经退行性变, 震颤, 脊髓固有神经元, 运动神经元, 反射, 建模, 运动控制, 振动, 神经障碍, 运动障碍, 计算神经科学

Abstract:

Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder.It typically involves a postural and motor tremor of the hands, head or other part of the body. Essential tremor is driven by a central oscillation signal in the brain. However, the corticospinal mechanisms involved in the generation of essential tremor are unclear. Therefore, in this study, we used a neural computational model that includes both monosynaptic and multisynaptic corticospinal pathways interacting with a propriospinal neuronal network. A virtual arm model is driven by the central oscillation signal to simulate tremor activity behavior.Cortical descending commands are classified as alpha or gamma through monosynaptic or multisynaptic corticospinal pathways, which converge respectively on alpha or gamma motoneurons in the spinal cord. Several scenarios are evaluated based on the central oscillation signal passing down to the spinal motoneurons via each descending pathway. The simulated behaviors are compared with clinical essential tremor characteristics to identify the corticospinal pathways responsible for transmitting the central oscillation signal. A propriospinal neuron with strong cortical inhibition performs a gating function in the generation of essential tremor. Our results indicate that the propriospinal neuronal network is essential for relaying the central oscillation signal and the production of essential tremor.

Key words: nerve regeneration, neurodegeneration, essential tremor, propriospinal neurons, motoneuron, reflex, modeling, motor control, oscillation, neurological disorder, movement disorder, computational neuroscience, neural regeneration