中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (1): 69-76.doi: 10.4103/1673-5374.224375

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

磁共振衰减流体转换复原序列血管高信号征不能作为大脑中动脉闭塞致急性缺血性脑卒中患者短期预后的预测因子

  

  • 收稿日期:2017-08-19 出版日期:2018-01-15 发布日期:2018-01-15
  • 基金资助:

     中国国家自然科学基金项目(81371521)

Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of ?uid-attenuated inversion recovery vascular hyperintensity scores

Chan-chan Li, Xiao-zhu Hao, Jia-qi Tian, Zhen-wei Yao, Xiao-yuan Feng, Yan-mei Yang   

  1. Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China
  • Received:2017-08-19 Online:2018-01-15 Published:2018-01-15
  • Contact: Yan-mei Yang, M.D.,yym9876@sohu.com,mifeisite2003@gmail.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81371521.

摘要:

既往研究显示,磁共振衰减流体转换复原序列血管高信号征可用于评估软脑膜侧枝循环,但在不同试验中其与预后情况差异较大。因此,本组试验设计对单侧大脑中动脉完全闭塞但不符合溶栓治疗条件的急性缺血性脑梗死患者进行了磁共振检查,然后对所有患者进行了90d的预后随访。结果发现,大脑中动脉闭塞后有效的软脑膜侧枝循环通过影响缺血半暗带和梗塞病灶,间接影响患者的神经功能恢复情况和短期临床预后,磁共振衰减流体转换复原序列血管高信号征虽然与90d时的临床预后(美国国立卫生院卒中量表评分)有关,但不足以作为短期临床预后的独立预测因子。

orcid:0000-0002-1972-4231(Yan-mei Yang)

关键词: 神经再生, 美国国立卫生院卒中量表, 大脑中动脉闭塞, 预后, 侧支循环, 改良Rankin量表评分, 脑缺血, 急性脑卒中, 扩散加权成像, 衰减流体转换复原序列

Abstract:

Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the present study was to assess a FVH score and explore its relationship with clinical outcomes. Patients with acute ischemic stroke due to middle cerebral artery M1 occlusion underwent magnetic resonance imaging and were followed up at 10 days (National Institutes of Health Stroke Scale) and 90 days (modified Rankin Scale) to determine short-term clinical outcomes. Effective collateral circulation indirectly improved recovery of neurological function and short-term clinical outcome by extending the size of the pial penumbra and reducing infarct lesions. FVH score showed no correlation with 90-day functional clinical outcome and was not sufficient as an independent predictor of short-term clinical outcome.

Key words: nerve regeneration, National Institutes of Health Stroke Scale, middle cerebral artery occlusion, collateral circulation, modified Rankin Scale score, cerebral ischemia,  , acute stroke, diffusion-weighted imaging, fluid-attenuated inversion recovery, neural regeneration