中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (8): 1309-1312.doi: 10.4103/1673-5374.235408

• 综述:神经损伤修复保护与再生 •    下一篇

不同发育阶段认知功能完整的ApoE4携带者和非携带者之间结构性脑容积的差异

  

  • 收稿日期:2018-05-29 出版日期:2018-08-15 发布日期:2018-08-15

Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan

Ryan J. Piers   

  1. Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA
  • Received:2018-05-29 Online:2018-08-15 Published:2018-08-15
  • Contact: Ryan J. Piers, M.A.,rpiers@bu.edu.

摘要:

载脂蛋白E4是阿尔茨海默病的显著遗传危险因素。文章目的在于总结在整个生命周期,即新生儿、儿童、少年、青年人、中年人、老年人中认知功能完整的载脂蛋白E4携带者和非携带者之间MRI检测的结构性脑容积的差异。这一领域的研究可能为进一步阐明载脂蛋白E4影响阿尔茨海默病发展的机制提供信息。

orcid:0000-0002-8901-9730(Ryan J. Piers)

关键词: MRI, 健康老化, 遗传风险因素, 生物标志物, 阿尔茨海默病

Abstract:

Apolipoprotein E4 (ApoE4) is a prominent genetic risk factor for Alzheimer’s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan (i.e., older adults,middle-aged adults, young adults, children and adolescents, and neonates). Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer’s disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.

Key words: MRI, healthy aging, genetic risk factor, biomarker, Alzheimer’s disease