中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (4): 621-631.doi: 10.4103/1673-5374.247466

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

揭示突触结合蛋白7在短期突触可塑性中功能的数学模型

  

  • 出版日期:2019-04-15 发布日期:2019-04-15
  • 基金资助:

    这项研究得到了新西兰林肯大学的资助

A mathematical model of synaptotagmin 7 revealing functional importance of short-term synaptic plasticity

Yao He, Don Kulasiri  , Jingyi Liang   

  1. Center for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand
  • Online:2019-04-15 Published:2019-04-15
  • Contact: Don Kulasiri, PhD, don.kulasiri@lincoln.ac.nz.
  • Supported by:

    This study was supported by a grant from Lincoln University, New Zealand.

摘要:

突触前钙传感器突触结合蛋白7在促进短期突触可塑性中具有重要作用,但其作用机制尚不清楚。研究试图通过开发捕获野生型和突触结合蛋白7敲除小鼠反应的数学模型来研究短期突触可塑性和突触后反应之间的潜在功能关系。然后研究了两种小鼠对多种输入动作电位的反应模型行为。这些行为可以确定短期突触可塑性在调节突触后反应和相关突触特性中的功能重要性。与先前的建模研究一致,研究显示释放位点受神经递质的非均匀释放概率控制。神经递质的非均匀释放的结构使得短期突触可塑性充当高通滤波器。研究还提出突触结合蛋白7可能是突触后反应长期变化的调节剂,有助于训练滤波器的目标频率。研究开发的短期突触可塑性数学模型解释了突触结合蛋白7在短期突触可塑性中的作用机制。

orcid: 0000-0001-8744-1578(Don Kulasiri)

关键词: 突触, 短期可塑性, 低频刺激, 高频刺激, 短期突触可塑性, 数学模型

Abstract:

Synaptotagmin 7 (Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in short-term synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes short-term synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.

Key words: synapse, short-term plasticity, short-term facilitation and depression, mathematical model, low-frequency stimulation, high-frequency stimulation