中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (7): 1152-1157.doi: 10.4103/1673-5374.251191

• 综述:退行性病与再生 • 上一篇    下一篇

EGb761对干细胞神经分化的影响可能为神经系统疾病治疗开辟一条新道路

  

  • 出版日期:2019-07-15 发布日期:2019-07-15
  • 基金资助:

    国家自然科学基金（81501185），山东省重点研究开发项目（2017GSF218043），烟台科技规划项目（2016WS017，2017WS105）

Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment

Chao Ren 1, 2  , Yong-Qiang Ji 3 , Hong Liu 2 , Zhe Wang 4 , Jia-Hui Wang 5 , Cai-Yi Zhang 6 , Li-Na Guan 7 , Pei-Yuan Yin 8   

  1. 1 Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    2 Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
    3 Department of Nephrology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
    4 Department of Clinical Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
    5 Department of Central Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
    6 Department of Emergency and Rescue Medicine, Xuzhou Medical University, Xuzhou, Jiangsu Province, China
    7 Department of Neurosurgical Intensive Care Unit, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
    8 Department of Blood Supply, Yantai Center Blood Station, Yantai, Shandong Province, China
  • Online:2019-07-15 Published:2019-07-15
  • Contact: Chao Ren, MD (Doctoral candidate), renchaotg@126.com; Cai-Yi Zhang, MD, 541315541@qq.com; Li-Na Guan, MD, guanlinatg@126.com.
  • Supported by:

    This work was funded by the National Natural Science Foundation of China, No. 81501185 (to CR); the Key Research & Development Project of Shandong Province of China, No. 2017GSF218043 (to CR); the Science and Technology Planning Project of Yantai of China, No. 2016WS017 (to LNG), 2017WS105 (to HL).

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摘要：

干细胞移植为神经系统疾病的治疗带来了新的希望，但其实现的关键仍是诱导干细胞定向分化成为所需的神经细胞。由于干细胞在体内外的分化受到多种因素的影响，其最终分化结果与其所处的微环境是密切相关的，因此探求诱导干细胞定向分化的最佳微环境成为研究的热点。一种来源于植物的、目前国内外认可的银杏叶提取物(Ginkgo biloba extract，EGb761)正逐渐成为干细胞研究者关注的重点之一。研究表明EGb761可以拮抗氧自由基、稳定细胞膜，且具有促进神经发生和突触发生，并提高脑源性神经营养因子的水平等作用，与干细胞神经向分化时所需环境具有相似性，故使得EGb761在干细胞诱导分化及移植时的应用提出了可能性。基于以上背景，文章从EGb761的组成、神经药理学入手，发现EGb761的一些重要成分对干细胞的分化及干细胞移植后良好微环境的保障具有重要作用，为将来进一步研究EGb761在神经系统疾病干细胞移植治疗中的作用提供了重要的参考依据。

orcid: 0000-0002-5418-3354 (Chao Ren)
           0000-0002-3756-6572 (Cai-Yi Zhang)
           0000-0001-7260-3706 (Li-Na Guan)

关键词: 银杏叶提取物, 银杏内酯B, 中药, 干细胞, 诱导分化, 干细胞移植, 神经系统疾病, 突触可塑性, 药理作用, 神经系统, 神经再生

Abstract:

Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differ¬entiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation outcome is strongly associated with the microenvironment in which the stem cells are located. Accordingly, the optimal microenvironment for inducing stem cell differentiation is a hot topic. EGb761 is extracted from the leaves of the Ginkgo biloba tree. It is used worldwide and is becoming one of the focuses of stem cell research. Studies have shown that EGb761 can antagonize oxygen free radicals, stabilize cell membranes, promote neurogenesis and synaptogenesis, increase the level of brain-derived neurotrophic factors, and replicate the environment required during the differentiation of stem cells into nerve cells. This offers the possibility of using EGb761 to induce the differentiation of stem cells, facilitating stem cell transplantation. To provide a comprehensive reference for the future application of EGb761 in stem cell therapy, we re¬viewed studies investigating the influence of EGb761 on stem cells. These started with the composition and neuropharmacology of EGb761, and eventually led to the finding that EGb761 and some of its important components play important roles in the differentiation of stem cells and the protection of a beneficial mi¬croenvironment for stem cell transplantation.

Key words: nerve regeneration, Ginkgo biloba extract, Ginkgolide B, traditional Chinese medicine, stem cells, induction of differentiation, stem cell transplantation, synaptic plasticity, pharmacological effect, neurological diseases, nervous systems, neural regeneration