中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (6): 1025-1028.doi: 10.4103/1673-5374.250581

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Rasmussen脑炎致单侧大脑皮质萎缩患者的运动诱发电位

  

  • 出版日期:2019-06-15 发布日期:2019-06-15

Ipsilateral motor evoked potentials in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis

Raffaele Nardone 1, 2, 3, 4 , Patrick B. Langthaler 2, 5 , Andrea Orioli 1 , Viviana Versace 6, 7 , Giuditta Ilaria Scarano 8 , Francesco Brigo 1, 9 , Leopold Saltuari 6, 7, 10 , Luca Carnicelli 1 , Eugen Trinka 2, 11, 12 , Luca Sebastianelli 6, 7   

  1. 1 Department of Neurology, Franz Tappeiner Hospital, Merano, Italy
    2 Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria
    3 Spinal Cord Injury and Tissue Regeneration Center, Salzburg, Austria
    4 Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie, Salzburg, Austria
    5 Department of Mathematics, Paris Lodron University of Salzburg, Austria
    6 Department of Neurorehabilitation, Hospital of Vipiteno, Vipiteno, Italy
    7 Research Unit for Neurorehabilitation South Tyrol, Bolzano, Italy
    8 Department of Psychology, Franz Tappeiner Hospital, Merano, Italy
    9 Department of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy
    10 Department of Neurology, Hochzirl Hospital, Zirl, Austria
    11 Centre for Cognitive Neurosciences Salzburg, Salzburg, Austria
    12 University for Medical Informatics and Health Technology, UMIT, Hall in Tirol, Austria
  • Online:2019-06-15 Published:2019-06-15
  • Contact: Raffaele Nardone, MD, PhD, raffaele.nardone@asbmeran-o.it.

摘要:

单侧大脑半球损伤后,同侧下行运动通路在恢复机制中的作用仍然知之甚少。试验应用经颅磁刺激(TMS)检测了1例56岁男性Rasmussen脑炎致左侧大脑半球萎缩患者患侧皮质脊髓通路的运动输出重组。患者TMS诱发患侧手部第一背骨间和腕伸肌运动诱发电位(MEPs)幅度高于10名年龄匹配的健康对照组受试者。与对照组相比,患者患侧肱二头肌MEP波幅第二大。从而表明,获得性单侧大脑皮质损伤患者未损伤运动皮质到偏瘫手的同侧运动投射增强。

orcid: 0000-0001-5243-6760 (Raffaele Nardone)

关键词: 经颅磁刺激, 运动皮质, 同侧运动诱发电位, 同侧运动通路, 拉斯穆森脑炎, 皮质萎缩, 大脑半球损伤, 神经再生

Abstract:

The role of the ipsilaterally descending motor pathways in the recovery mechanisms after unilateral hemispheric damage is still poorly understood. Motor output reorganization was investigated in a 56-year-old male patient with acquired unilateral hemispheric atrophy due to Rasmussen encephalitis. In particular, the ipsilateral corticospinal pathways were explored using focal transcranial magnetic stimulation. In the first dorsal interosseous and wrist extensors muscles, the median amplitudes of the ipsilateral motor evoked potentials induced by transcranial magnetic stimulation in the patient were higher than those of 10 age-matched healthy control subjects. In the biceps brachii muscle, the median amplitudes of the ipsilateral motor evoked potentials were the second largest in the patient compared to the controls. This study demonstrated a reinforcement of ipsilateral motor projections from the unaffected motor cortex to the hemiparetic hand in a subject with acquired unihemispheric cortical damage.

Key words: transcranial magnetic stimulation, motor cortex, ipsilateral motor evoked potentials, ipsilateral motor pathways, Rasmussen encephalitis, cortical atrophy, hemispheric damage