中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1343-1351.doi: 10.4103/1673-5374.253511

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

脱细胞神经导管和许旺细胞移植是周围神经损伤有效的治疗策略

  

  • 出版日期:2019-08-15 发布日期:2019-08-15
  • 基金资助:

    国家重点研究开发计划(2017YFA0104701(TOYW)、国家自然科学基金(31771052)、北京自然科学基金[7172202]、中国人民解放军医学青年培训项目[16QNP144)]

Therapeutic strategies for peripheral nerve injury:decellularized nerve conduits and Schwann cell transplantation

Gong-Hai Han 1, 2 , Jiang Peng 2 , Ping Liu 3 , Xiao Ding 4 , Shuai Wei 4 , Sheng Lu 5 , Yu Wang 2   

  1. 1 Kunming Medical University, Kunming, Yunnan Province, China
    2 Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China
    3 Shanxi Medical University, Taiyuan, Shanxi Province, China
    4 Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China
    5 920 th Hospital of Joint Service Support Force, Kunming, Yunnan Province, China
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Sheng Lu, MD, drlusheng@163.com; Yu Wang, PhD, wangwangdian628@126.com.
  • Supported by:

    This work was supported by the National Key R & D Program of China, No. 2017YFA0104701 (to YW); the National Natural Science Foundation of China, No. 31771052 (to YW); the Natural Science Foundation of Beijing of China, No. 7172202 (to YW); the PLA Youth Training Project for Medical Science of China, No. 16QNP144 (to YW).

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摘要：

近年来，采用许旺细胞移植的方法修复周围神经损伤备受关注。基于动物实验研究表明，保留细胞外基质组分的去细胞神经复合许旺细胞移植可促进周围神经损伤的修复，并且相关文献报道，自体许旺细胞移植修复周围神经损伤已应用于临床。文章综述了周围神经去细胞的方法、细胞外基质的组成和功能、许旺细胞的发育、分泌和成髓鞘以及许旺细胞移植修复周围神经损伤。文献资料表明，去细胞神经导管复合许旺细胞是治疗周围神经损伤的有效策略，为周围神经损伤的临床修复提供了更广阔的思路。

orcid: 0000-0001-7532-8981 (Sheng Lu)
           0000-0001-7811-5834 (Yu Wang)

关键词: 周围神经损伤, 周围神经疾病, 神经导管, 去细胞技术, 去细胞神经, 去细胞方法, 细胞外基质成分, 细胞外基质功能, 许旺细胞发育, 许旺细胞髓鞘化, 许旺细胞移植, 神经再生

Abstract:

In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.

Key words: nerve regeneration, peripheral nerve injury, nerve conduits, decellularization, extracellular matrix, Schwann cell, neural regeneration