中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (5): 955-962.doi: 10.4103/1673-5374.297062

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

经颅磁刺激在糖尿病性神经病变中的应用及前景

  

  • 出版日期:2021-05-15 发布日期:2020-12-29
  • 基金资助:

    南通市科技攻关项目(JC2018060)

Prospects for the application of transcranial magnetic stimulation in diabetic neuropathy

Xi Xu1, Dong-Sheng Xu2, 3, *   

  1. 1 Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China;  2 Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China;  3 School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • Online:2021-05-15 Published:2020-12-29
  • Contact: Dong-Sheng Xu, MD, dxu0927@shutcm.edu.cn.
  • Supported by:
    This work was financially supported by the Science and Technology Project of Nantong City of China, No. JC2018060 (to XX). 

摘要: https://orcid.org/0000-0002-8477-5377 (Dong-Sheng Xu)

关键词:

中枢神经系统, 可塑性, 恢复, 再生, 周围神经, 疼痛, 抑郁, 血管, 自主神经病变, 氧化应激, 炎症

Abstract: Encouraging results have been reported for the use of transcranial magnetic stimulation-based nerve stimulation in studies of the mechanisms of neurological regulation, nerve injury repair, and nerve localization. However, to date, there are only a few reviews on the use of transcranial magnetic stimulation for diabetic neuropathy. Patients with diabetic neuropathy vary in disease progression and show neuropathy in the early stage of the disease with mild symptoms, making it difficult to screen and identify. In the later stage of the disease, irreversible neurological damage occurs, resulting in treatment difficulties. In this review, we summarize the current state of diabetic neuropathy research and the prospects for the application of transcranial magnetic stimulation in diabetic neuropathy. We review significant studies on the beneficial effects of transcranial magnetic stimulation in diabetic neuropathy treatment, based on the outcomes of its use to treat neurodegeneration, pain, blood flow change, autonomic nervous disorders, vascular endothelial injury, and depression. Collectively, the studies suggest that transcranial magnetic stimulation can produce excitatory/inhibitory stimulation of the cerebral cortex or local areas, promote the remodeling of the nervous system, and that it has good application prospects for the localization of the injury, neuroprotection, and the promotion of nerve regeneration. Therefore, transcranial magnetic stimulation is useful for the screening and early treatment of diabetic neuropathy. transcranial magnetic stimulation can also alleviate pain symptoms by changing the cortical threshold and inhibiting the conduction of sensory information in the thalamo-spinal pathway, and therefore it has therapeutic potential for the treatment of pain and pain-related depressive symptoms in patients with diabetic neuropathy. Additionally, based on the effect of transcranial magnetic stimulation on local blood flow and its ability to change heart rate and urine protein content, transcranial magnetic stimulation has potential in the treatment of autonomic nerve dysfunction and vascular injury in diabetic neuropathy. Furthermore, oxidative stress and the inflammatory response are involved in the process of diabetic neuropathy, and transcranial magnetic stimulation can reduce oxidative damage. The pathological mechanisms of diabetic neuropathy should be further studied in combination with transcranial magnetic stimulation technology.

Key words: autonomic neuropathy, central nervous system, depression, inflammation, oxidative stress, pain, peripheral nerve, plasticity, recovery, regeneration, vascular