中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1554-1555.doi: 10.4103/1673-5374.303017

• 观点:退行性病与再生 • 上一篇    下一篇

蛋白质相互作用PROTAC作为阿尔茨海默病治疗药物开发的通用多靶点治疗方法

  

  • 出版日期:2021-08-15 发布日期:2021-01-13

Application of PROTAC strategy to TTR-Aβ protein-protein interaction for the development of Alzheimer’s disease drugs

Nicoló Tonali, Susanna Nencetti, Elisabetta Orlandini, Lidia Ciccone*   

  1. Université Paris-Saclay, CNRS, BioCIS, 
    Châtenay-Malabry, France (Tonali N)
    Department of Pharmacy, University of Pisa, Pisa, Italy (Nencetti S, Ciccone L)
    Department of Earth Sciences, Research Center “E. Piaggio”, University of Pisa, Pisa, Italy (Orlandini E)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Lidia Ciccone, lidia.ciccone@unipi.it.
  • Supported by:
    We thank Italian Ministero dell’Istruzione, dell’Universitá e della Ricerca (PRIN 2017SNRXH3) and PRA_2018_20 Approcci Target/Multitarget per il disegno e lo sviluppo di Small Molecules per terapie innovative. 

摘要: https://orcid.org/0000-0002-2762-1929 
(Lidia Ciccone)

关键词:

Abstract: Alzheimer’s disease (AD) is a complex and multifaced neurodegenerative disorder for which the precise pathological molecular mechanisms are still not completely known.