中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (1): 15-19.doi: 10.4103/1673-5374.314284

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

二甲双胍如何改善化疗脑的记忆障碍

  

  • 出版日期:2022-01-05 发布日期:2021-09-17

Research advances on how metformin improves memory impairment in “chemobrain”

Ahmad Alhowail1, *, Sridevi Chigurupati2   

  1. 1Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, Kingdom of Saudi Arabia; 2Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia
  • Online:2022-01-05 Published:2021-09-17
  • Contact: Ahmad Alhowail, PhD, aalhowail@qu.edu.sa.
  • Supported by:
    This work was supported by the Deanship of Scientific Research, Qassim University.

摘要:

约70%癌症幸存者存在由化疗引起的认知障碍,即化疗脑。然而,尚未不清楚化疗如何诱发认知功能障碍,且缺乏针对该问题的临床治疗策略。有研究显示2型糖尿病的一线治疗药物二甲双胍可减轻化疗药物的不良作用。近年来一些研究开始关注二甲双胍在减轻化疗脑方面的作用。作者在综述在分析了化疗脑机制的临床以及临床前研究,评估了二甲双胍在改善化疗脑方面的作用及潜在机制。

https://orcid.org/0000-0003-1427-032X (Ahmad Alhowail)

关键词: 二甲双胍, 神经保护剂, 化疗脑, 化疗, 认知障碍, 记忆障碍, 行为任务, 炎症, 综述

Abstract: Cognitive impairment caused by chemotherapy, referred to as “chemobrain,” is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. Recently, several studies have examined the effect of metformin in rescuing chemobrain. This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.

Key words: behavioral task, chemobrain, chemotherapy, cognitive impairments, inflammation, memory impairment, metformin, neuroprotective agent, review