中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (7): 1576-1581.doi: 10.4103/1673-5374.327361

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

新冠肺炎幸存者脑低频波动幅度变化:一项为期1年的观察性队列静息状态功能磁共振成像研究

  

  • 出版日期:2022-07-15 发布日期:2022-01-18
  • 基金资助:
    中国新冠肺炎疫情重点应急项目(2020SK3006);湖南省医学影像临床研究中心项目(2020SK4001);湖南省抗击新冠肺炎创新性重大突发事件专项资金(2020SK3014)

Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up

Yan-Yao Du1, #, Wei Zhao1, 4, #, Xiang-Lin Zhou2, #, Mu Zeng1, Dan-Hui Yang2, Xing-Zhi Xie1, Si-Hong Huang1, Ying-Jia Jiang1, Wen-Han Yang1, Hu Guo1, Hui Sun1, Ji-Yang Liu3, Ping Liu3, Zhi-Guo Zhou3, *, Hong Luo2, *, Jun Liu1, 4, 5, *   

  1. 1Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 2Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 3Department of Respiratory Medicine, The First Hospital of Changsha, Changsha, Hunan Province, China; 4Clinical Research Center for Medical Imaging in Hunan Province, Changsha, Hunan Province, China; 5Department of Radiology Quality Control Center, Hunan Province, Changsha, Hunan Province, China
  • Online:2022-07-15 Published:2022-01-18
  • Contact: Jun Liu, MD, junliu123@csu.edu.cn; Hong Luo, MD, luohong1003@163.com; Zhi-Guo Zhou, MD, 13807311490@163.com.
  • Supported by:
    This study was supported by Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection of China, No. 2020SK3006 (to JL); Clinical Research Center for Medical Imaging in Hunan Province of China, No. 2020SK4001 (to JL); and the Innovative Major Emergency Project Funding against the New Coronavirus Pneumonia in Hunan Province of China, No. 2020SK3014 (to JYL).

摘要:

短期随访已证实新冠肺炎幸存者存在焦虑、抑郁以及大脑微观结构方面的变化,但新冠肺炎后是否有长期的影响尚不可知。因此此次观察性队列研究收集了22例新冠肺炎幸存者(8男11女,年龄54.210±8.696岁)住院与随访1年的临床数据,结果显示出院1年后,疲劳和肌痛仍然很常见,随着时间的延长失眠变得更为明显。静息态功能磁共振显示,与29名健康对照者(7男18女,年龄50.480±11.576岁)相比,随访1年时新冠肺炎幸存者大脑左中央前回、额中回、岛盖部额下回、三角部额下回、岛叶、海马、海马旁回、梭状回、中央后回、顶叶下角回、缘上回,角回、丘脑、颞中回、颞下回、尾状核和壳核的低频振幅明显增加。且新冠肺炎幸存者大脑左侧尾状核的低频振幅值与康复者的阿森斯失眠量表评分呈明显正相关,且左侧中央前回的低频振幅值也与住院期间中性粒细胞计数呈正相关。长期随访结果提示,新冠肺炎幸存者与情绪和睡眠调节相关的脑区存在低频波动幅度的变化,可能有助于了解新冠病毒相关神经精神后遗症的神经生物学机制。研究于2020年3月19日经中南大学湘雅二医院伦理委员会批准(批准号2020S004)。

https://orcid.org/0000-0002-7851-6782 (Jun Liu); https://orcid.org/0000-0002-9501-651X (Hong Luo); https://orcid.org/0000-0002-7621-7156 (Zhi-Guo Zhou)

关键词: COVID-19, 静息态, 功能磁共振成像, 低频振幅, 长期预后, 神经精神后遗症, 随访研究, 临床研究

Abstract: Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019 (COVID-19) exhibit anxiety, depression, and altered brain microstructure, their long-term physical problems, neuropsychiatric sequelae, and changes in brain function remain unknown. This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19 (8 males and 11 females, aged 54.2 ± 8.7 years). Fatigue and myalgia were persistent symptoms at the 1-year follow-up. The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls (7 males and 18 females, aged 50.5 ± 11.6 years), COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation (ALFF) values in the left precentral gyrus, middle frontal gyrus, inferior frontal gyrus of operculum, inferior frontal gyrus of triangle, insula, hippocampus, parahippocampal gyrus, fusiform gyrus, postcentral gyrus, inferior parietal angular gyrus, supramarginal gyrus, angular gyrus, thalamus, middle temporal gyrus, inferior temporal gyrus, caudate, and putamen. ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores, and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization. The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors. This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae. This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University (approval No. 2020S004) on March 19, 2020.

Key words: amplitude of low-frequency fluctuation, clinical study, coronavirus disease 2019, follow-up, functional magnetic resonance imaging, long-term physical consequences, neuropsychiatric sequelae, resting‐-state function